ArticleMolecular reproduction and development2011
Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.
Article in Molecular reproduction and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis.Nature communications · 2025Article
- Distinct roles of haspin in stem cell division and male gametogenesis.Scientific reports · 2021Article
- Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis.Oncotarget · 2016Article
- Cytoplasmic localization of SBR (Dm NXF1) protein and its zonal distribution in the ganglia of Drosophila melanogaster larvae.Invertebrate neuroscience : IN · 2016Article
- Nuclear export of messenger RNA.Genes · 2015Review
- RNA Export through the NPC in Eukaryotes.Genes · 2015Review
- Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.Human molecular genetics · 2014Article
- Evolutionarily diverged regulation of X-chromosomal genes as a primal event in mouse reproductive isolation.PLoS genetics · 2014Article
- A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.Biology of reproduction · 2013Article
- Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.PloS one · 2013Article
- MNS1 is essential for spermiogenesis and motile ciliary functions in mice.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In eukaryotes, mRNA is actively exported to the cytoplasm by a family of nuclear RNA export factors (NXF). Four Nxf genes have been identified in the mouse: Nxf1, Nxf2, Nxf3, and Nxf7. Inactivation of Nxf2, a germ cell-specific gene, causes defects in spermatogenesis. Here we report that Nxf3 is expressed exclusively in Sertoli cells of the postnatal testis, in a developmentally regulated manner. Expression of Nxf3 coincides with the cessation of Sertoli cell proliferation and the beginning of their differentiation. Continued expression of Nxf3 in mature Sertoli cells of the adult is spermatogenesis stage-independent. Nxf3 is not essential for spermatogenesis, however, suggesting functional redundancy among Nxf family members. With its unique expression pattern in the testis, the promoter of Nxf3 can be used to drive postnatal Sertoli cell-specific expression of other proteins such as Cre recombinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.