ArticleCurrent infectious disease reports2010
Clostridial myonecrosis: new insights in pathogenesis and management.
Article in Current infectious disease reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Pediatric Clostridium septicum infections: a systematic review and case-based perspective.BMC pediatrics · 2026Pooled it
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- Clinical characteristics and prognostic factors ofFrontiers in medicine · 2026Article
- FatalPathogens (Basel, Switzerland) · 2025Review
- BrnQ Branched-Chain Amino Acid Transporters Influence Toxin Production by, but Not Growth of,Toxins · 2025Article
- Fatal sepsis case and finding ofIDCases · 2025Article
- The presence of differentiated C2C12 muscle cells enhances toxin production and growth byVirulence · 2024Article
- Unveiling the pathogenic mechanisms ofEmerging microbes & infections · 2024Review
- Article
- Review
- Clostridium myonecrosis - a rare and underdiagnosed condition in the elderly: a case with severe skipping lesions and an overview of treatment guidelines.International journal of emergency medicine · 2022Article
- Piceatannol AlleviatesMolecules (Basel, Switzerland) · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Article
- Toll-Like Receptor 4 Protects AgainstFrontiers in cellular and infection microbiology · 2021Article
- Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient.CEN case reports · 2020Article
- The Agr-Like Quorum-Sensing System Is Important formSphere · 2020Article
- Amentoflavone AttenuatesFrontiers in pharmacology · 2020Article
- Immunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Review
- Inflammasome Activation Induced by Perfringolysin O ofFrontiers in microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridial myonecrosis remains an important cause of human morbidity and mortality worldwide. Although traumatic gas gangrene can be readily diagnosed from clinical findings and widely available technologies, spontaneous gas gangrene is more insidious, and gynecologic infections due to Clostridium sordellii progress so rapidly that death often precedes diagnosis. In each case, extensive tissue destruction and the subsequent systemic manifestations are mediated directly and indirectly by potent bacterial exotoxins. The management triumvirate of timely diagnosis, thorough surgical removal of necrotic tissue, and treatment with antibiotics that inhibit toxin synthesis remains the gold standard of care. Yet, despite these measures, mortality remains 30% to 100% and survivors often must cope with life-altering amputations. Recent insights regarding the genetic regulation of toxin production, the molecular mechanisms of toxin-induced host cell dysfunction, and the roles of newly described toxins in pathogenesis suggest that novel prevention, diagnostic, and treatment modalities may be on the horizon for these devastating infections.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.