Evidence map›Paper›PMID 21308452›Full record

ArticleCurrent infectious disease reports2011

Current concepts of the intestinal microbiota and the pathogenesis of infection.

Leslie H Wardwell, Curtis Huttenhower, Wendy S Garrett

Open access · greenAbstract read
In one paragraph

Article in Current infectious disease reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power Performance.Journal of strength and conditioning research · 2020
    Article
  10. Frontiers in microbiology · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. The Burden of Enteropathy and "Subclinical" Infections.Pediatric clinics of North America · 2017
    Review
  17. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Leslie H WardwellDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, SPH 1 909, Boston, MA, 02115, USA, wardwell@fas.harvard.edu.
Curtis Huttenhower
Wendy S Garrett
Harvard University · US

Funding

Gut microbiota and inflammatory monocytes in colorectal cancerR01CA154426 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2011 to 2025
$5.2M
Functional activity and inter-organismal interactions in the human microbiomeR01HG005969 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUTTENHOWER, CURTIS · 2010 to 2012
$1.3M
Disease Initation and the role of DCs in the TRUC Model of ulcerative colitisK08AI078942 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2009 to 2013
$665k
NCI NIH HHS R01 CA154426NHGRI NIH HHS R01 HG005969NIAID NIH HHS K08 AI078942
6 · The paper itself

Abstract

The human gastrointestinal tract is populated by a vast and diverse community of microbes. This gut microbiota participates in host metabolism, protects from invading microbes, and facilitates immune system development and function. In this review, we consider the contributions of intestinal microbes to the pathogenesis of infectious diseases. Key concepts of colonization resistance, host-commensal microbe interaction in immunity, antibiotics and gut bacterial communities, viral-gut bacterial interactions, and evolving methods for studying commensal microbes are explored.

Identifiers

PMID21308452
PMCPMC3077078
OpenAlexW2043239636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.