Evidence map›Paper›PMID 21308420›Full record

ReviewLipids2011

Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors.

Leah G Gillingham, Sydney Harris-Janz, Peter J H Jones

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Lipids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 200 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 9 pooled it
27.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00927199 phase2completednot on this map

Efficacy of Consumption of High-oleic Canola and Flaxseed Oils in the Management of Hypercholesterolemia and Other Cardiovascular Risk Factors

TypeinterventionalSponsorUniversity of ManitobaRan2007 to 2008Enrolled36ConditionsCardiovascular DiseaseArmsHigh-Oleic Canola Oil, High-Oleic Canola/Flaxseed Oil Blend, Western Dietary Control
NCT06818032 nacompletednot on this mapstarted 2025, after this paper: background citation

Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2025 to 2026Enrolled30ConditionsHealthy, Healthy Volunteer, Healthy Volunteers, Healthy AdultArmsNegative control, Avocado, Fat and fiber addition
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 9 syntheses or guidelines pooled it, 543 citations in OpenAlex.

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  9. Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2014
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  20. Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Leah G GillinghamDepartment of Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB, R3T 2N2, Canada.
Sydney Harris-Janz
Peter J H Jones
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critical assessment of the current body of evidence surrounding efficacy of dietary monounsaturated fatty acids (MUFA) for reduction of traditional risk factors defining metabolic syndrome (MetS) and CVD. Due to existing and emerging research on health attributes of MUFA rich diets, and to the low prevalence of chronic disease in populations consuming MUFA rich Mediterranean diets, national dietary guidelines are increasingly recommending dietary MUFA, primarily at the expense of saturated fatty acids (SFA). Consumption of dietary MUFA promotes healthy blood lipid profiles, mediates blood pressure, improves insulin sensitivity and regulates glucose levels. Moreover, provocative newer data suggest a role for preferential oxidation and metabolism of dietary MUFA, influencing body composition and ameliorating the risk of obesity. Mounting epidemiological and human clinical trial data continue to demonstrate the cardioprotective activity of the MUFA content of dietary fat. As the debate on the optimal fatty acid composition of the diet continues, the benefit of increasing MUFA intakes, particularly as a substitute for dietary SFA, deserves considerable attention.

Indexed as

AnimalsCardiovascular DiseasesCytoprotectionDietary FatsFatty Acids, MonounsaturatedHumansLipid MetabolismLipidsMetabolic SyndromeRisk FactorsDietary FatsFatty Acids, MonounsaturatedLipids

Identifiers

PMID21308420
OpenAlexW1982850726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.