ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2011
Prevalence of pilus-encoding islets and clonality of pneumococcal isolates from children with acute otitis media.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nonencapsulated Streptococcus pneumoniae Cause Acute Otitis Media in the Chinchilla That Is Enhanced by Pneumococcal Surface Protein K.Open forum infectious diseases · 2014Article
- Clonality behind the increase of multidrug-resistance among non-invasive pneumococci in Southern Finland.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.PloS one · 2012Article
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Authors and funding
4 authors.
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Abstract
We characterized the prevalence of pilus islets 1 (PI-1) and 2 (PI-2) and the clonality of Streptococcus pneumoniae isolates taken from children with acute otitis media (AOM) to study the association between pilus existence and AOM disease potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance. The study material consisted of 75 pneumococcal isolates cultured from the middle ear fluid and/or nasopharyngeal aspirate of 56 children with AOM in Finland during the period 1990-1992. Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal PI-1 and PI-2 genes. All isolates were susceptible to penicillin, 14 different serotypes were found, and 20% of the isolates were positive for PI-1 genes. PI-2 genes were not found. MLST showed high heterogeneity: 52 AOM isolates belonged to 18 known clonal complexes (CC). PI-1 was associated with serotypes 6A, 6B, and 9V, and genotype CC490. In the time prior to 7-valent pneumococcal conjugate vaccine (PCV7) and increased antimicrobial resistance, pneumococcal AOM isolates carried PI-1 genes at a rather low prevalence. PI-2 genes were not detected. PI-1 was related to serotype rather than genotype. The importance of PI-1 in AOM infections and its association with the spread of antimicrobial resistance requires further research.
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