ArticlePediatric nephrology (Berlin, Germany)2011
Implications for kidney disease in obese children and adolescents.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Association of weight-adjusted waist index and Albuminuria in children and adolescents: A national population-based study.PloS one · 2025Article
- Renoprotection by Inhibiting Connexin 43 Expression in a Mouse Model of Obesity-Related Renal Injury.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Tangled relationship between insulin resistance and microalbuminuria in children with obesity.World journal of clinical pediatrics · 2022Review
- Effect of pre and post-transplant body mass index on pediatric kidney transplant outcomes.BMC pediatrics · 2022Article
- Glomerular Hyperfiltration Is Associated with Liver Disease Severity in Children with Nonalcoholic Fatty Liver Disease.The Journal of pediatrics · 2020Article
- High uric acid, reduced glomerular filtration rate and non-alcoholic fatty liver in young people with obesity.Journal of endocrinological investigation · 2020Article
- Can childhood obesity influence later chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2019Review
- Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics.Italian journal of pediatrics · 2018Review
- Article
- Deteriorated glucose metabolism with a high-protein, low-carbohydrate diet in db mice, an animal model of type 2 diabetes, might be caused by insufficient insulin secretion.European journal of nutrition · 2017Article
- Article
- Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children.Journal of clinical research in pediatric endocrinology · 2016Article
- Determination of early urinary renal injury markers in obese children.Pediatric nephrology (Berlin, Germany) · 2015Article
- Kidney size and function in a multi-ethnic population-based cohort of school-age children.Pediatric nephrology (Berlin, Germany) · 2014Article
- Limited value of routine microalbuminuria assessment in multi-ethnic obese children.Pediatric nephrology (Berlin, Germany) · 2013Article
- Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice.European journal of nutrition · 2013Article
- Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study.BMC research notes · 2012Article
- Impact of obesity on drug metabolism and elimination in adults and children.Clinical pharmacokinetics · 2012Review
- The possible role of esRAGE and sRAGE in the natural history of diabetic nephropathy in childhood.Pediatric nephrology (Berlin, Germany) · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing attention has been focused on the implications of obesity in adults on the development of kidney disease, but data on the obese pediatric population are lacking. The aim of this study was to investigate whether changes in various renal function indexes/markers, as expressed by the glomerular filtration rate [GFR, as estimated by the Schwartz formula (eGFR)], serum cystatin C (CysC) level, albumin excretion rate (AER), and modifications in nitric oxide (NO; an important modulator of renal function and morphology), urinary isoprostanes (markers of oxidative stress), and blood pressure (BP), can be detected in obese children and adolescents when compared to normal weight controls. Blood and urinary samples were collected to evaluate markers of renal function, serum and urinary NO, and urinary isoprostanes in 107 obese Caucasian subjects and 50 controls. Ambulatory BP monitoring (ABPM) was performed in all cases. Obesity was expressed by the body mass index standard deviation score (SDS-BMI), and insulin resistance by the homeostasis model assessment of insulin resistance (HOMA-IR). CysC and eGFR did not significantly differ between the two groups; AER was increased in obese children. CysC and GFR were related to HOMA-IR, and AER was related to HOMA-IR and SDS-BMI. Obese subjects had reduced NO levels and increased urinary isoprostanes and BP measurements; all three parameters were related to SDS-BMI and insulin resistance. ABPM showed an increased incidence of hypertension and non-dipping in the obese group. Based on our comparison of obese and nonobese children, we conclude that renal involvement is not an early clinically evident manifestation of adiposity in childhood, since no overt changes in eGFR and only a mild albuminuria were detected. A longer exposure to obesity is probably needed before renal function impairment appears.
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