ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Septic cardiomyopathy: hemodynamic quantification, occurrence, and prognostic implications.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 88 citations in OpenAlex.
- Protective effect of Xuebijing injection on myocardial injury in patients with sepsis: a randomized clinical trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2016Trial
- The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study.BioMed research international · 2016Trial
- [Vasopressors in septic shock: the old and the new].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Septic Cardiomyopathy: Age-Dependent Physiology and Hemodynamic Aspects-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- The Role of Pyroptosis in Exacerbating Sepsis-Induced Myocardial Injury: Mechanisms and Implications.Journal of inflammation research · 2026Review
- Sepsis-Related Cardiomyopathy: Advances in Diagnosis and Treatment.Reviews in cardiovascular medicine · 2025Review
- [Septic cardiomyopathy-diagnosis and estimation of disease severity].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
- Treatment of patients with multiple organ dysfunction syndrome (MODS) with an electromagnetic field coupled to biorhythmically defined impulse configuration: the MicrocircMODS study.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Therapeutic Strategies Targeting Mitochondrial Dysfunction in Sepsis-induced Cardiomyopathy.Cardiovascular drugs and therapy · 2024Review
- Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review.Emergency medicine international · 2023Review
- Afterload-related cardiac performance is a powerful hemodynamic predictor of mortality in patients with chronic heart failure.Therapeutic advances in chronic disease · 2023Article
- Utility of Cardiac Power Hemodynamic Measurements in the Evaluation and Risk Stratification of Cardiovascular Conditions.Healthcare (Basel, Switzerland) · 2022Review
- Review
- Septic cardiomyopathy: Diagnosis and management.Journal of intensive medicine · 2022Review
- Afterload-related cardiac performance predicts prognosis in critical ill patients with sepsis: A prospective observational pilot study.Medicine · 2021Observational
- Clinical and Laboratory Parameters Associated with Septic Myocardial Dysfunction in Children with Septic Shock.Indian journal of pediatrics · 2021Article
- Role of Concomitant Coronary Artery Bypass Grafting in Valve Surgery for Infective Endocarditis.Journal of clinical medicine · 2021Article
- Pathophysiology of sepsis-induced cardiomyopathy.Nature reviews. Cardiology · 2021Review
- Afterload-related cardiac performance identifies cardiac impairment and associates with outcome in patients with septic shock: a retrospective cohort study.Journal of intensive care · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn sepsis, severe reduction of afterload may often mask cardiac impairment. By establishing the parameter "afterload-related cardiac performance (ACP)" we wanted to determine the extent, frequency, and prognostic relevance of septic cardiomyopathy.
methodsOver a 12 months period, all patients of our medical intensive care ward were included into the study when they were classified as having "septic MODS" (sepsis score ≥12 as long as APACHE II score was ≥20). Hemodynamic assessments were performed using a pulmonary artery catheter.
resultsA total of 524 patients were screened, and from these 39 had septic MODS. In survivors, APACHE II score values declined from day 0 (day of diagnosis, 27.6 ± 8.0) to day 4 (17.8 ± 8.0), while in non-survivors, score values remained high (day 0: 31.8 ± 5.7; day 4: 33.2 ± 6.7; p < 0.001). Hemodynamic measurements showed an inverse correlation of cardiac output (CO(measured)) and SVR which can be described as CO = β (0) × SVR( β1). The upper limit of 80% tolerance range of CO was defined as the "normal" CO values (CO(normal)). The parameter "afterload-related cardiac performance (ACP)" was calculated as ACP (%) = CO(measured)/CO(normal) × 100. It turned out that ACP shows a stronger correlation with APACHE II- and sepsis-score than CO, cardiac index (CI), cardiac power (CPO), or cardiac power index (CPI). Furthermore, ACP correlated with sepsis-induced myocardial damage as indicated by elevations of troponin I and significantly differed between surviving (86.9 ± 1.6%) and non-surviving patients (69.2 ± 1.4%; p < 0.0001). While 75% of the surviving patients showed an ACP >60%, 38% of the non-survivors had a moderate (ACP 40-60%) and 25% a severe impairment of cardiac function (ACP < 40%).
conclusionBy using the parameter "afterload-related cardiac performance, ACP", the impairment of cardiac function can be reliably quantified showing that septic cardiomyopathy occurs frequently and is of prognostic relevance in patients with septic MODS.
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