ArticleNature2011
Charting a course for genomic medicine from base pairs to bedside.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 426 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The MedSeq Project Pilot Study: Integrating Whole Genome Sequencing Into the Practice of Clinical Medicine
Personalized Genomic Testing for Skin Cancer - Maximizing Utility and Reach
Reporting Adult-Onset Genomic Results to Pediatric Biobank Participants and Parents
Who cites it
426 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review.Frontiers in pharmacology · 2024Pooled it
- Effectiveness of Artificial Intelligence for Personalized Medicine in Neoplasms: A Systematic Review.BioMed research international · 2022Pooled it
- Patient experience of uncertainty in cancer genomics: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Pooled it
- The effect of communicating the genetic risk of cardiometabolic disorders on motivation and actual engagement in preventative lifestyle modification and clinical outcome: a systematic review and meta-analysis of randomised controlled trials.The British journal of nutrition · 2016Pooled it
- Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial.Nature medicine · 2022Trial
- Pragmatic Trials in Genomic Medicine: The Integrating Pharmacogenetics In Clinical Care (I-PICC) Study.Clinical and translational science · 2020Trial
- Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.Circulation · 2019Trial
- EMR documentation of physician-patient communication following genomic counseling for actionable complex disease and pharmacogenomic results.Clinical genetics · 2017Trial
- Guiding Oncology Patients Through the Maze of Precision Medicine.Journal of health communication · 2016Trial
- What Is Precision Psychotherapy?The Journal of medicine and philosophy · 2026Article
- Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.Nature reviews. Cardiology · 2026Review
- Development and Evaluation of a Culturally TargetedKidney medicine · 2025Article
- Proactive process evaluation of precision medicine platforms: a roadmap.BMJ health & care informatics · 2025Article
- A Transformers-based framework for refinement of genetic variants.Frontiers in bioinformatics · 2025Article
- Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis.Nature cancer · 2024Article
- Fast and accurate DNASeq variant calling workflow composed of LUSH toolkit.Human genomics · 2024Article
- DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.Human molecular genetics · 2024Article
- The ethical challenges of diversifying genomic data: A qualitative evidence synthesis.Cambridge prisms. Precision medicine · 2024Review
- Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- To boldly go: Unpacking the NHGRI's bold predictions for human genomics by 2030.American journal of human genetics · 2023Article
366 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been much progress in genomics in the ten years since a draft sequence of the human genome was published. Opportunities for understanding health and disease are now unprecedented, as advances in genomics are harnessed to obtain robust foundational knowledge about the structure and function of the human genome and about the genetic contributions to human health and disease. Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine.
Indexed as
Identifiers
21307933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.