Evidence map›Paper›PMID 21307847›Full record

ReviewMucosal immunology2011

Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda.

A J Griffin, S J McSorley

Open access · bronzeAbstract readReview
In one paragraph

Review in Mucosal immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 135 citations in OpenAlex.

  1. Differential effects of BCG vaccine on immune responses induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. A systems pharmacology-basedFrontiers in veterinary science · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Metabolic Analysis of Intracellular Pathogenic Bacteria Using NMR.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Oral Immunization with AttenuatedMicrobiology spectrum · 2022
    Article
  19. Encapsulation ofFrontiers in microbiology · 2022
    Article
  20. Protective immunity enhancedFrontiers in immunology · 2022
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

A J GriffinDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Center for Infectious Diseases and Microbiology Translational Research, McGuire Translational Research Facility, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
S J McSorley
University of Minnesota · USUniversity of Minnesota System · US

Funding

Sustained adaptive immunity in the mucosaP01AI056172 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T · 2003 to 2017
$22.3M
CD4 T Cell Response to SalmonellaR01AI055743 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCSORLEY, STEPHEN J · 2004 to 2013
$3.5M
NIAID NIH HHS AI055743NIAID NIH HHS AI56172NIAID NIH HHS P01 AI056172NIAID NIH HHS R01 AI055743
6 · The paper itself

Abstract

Salmonella infections can cause a range of intestinal and systemic diseases in human and animal hosts. Although some Salmonella serovars initiate a localized intestinal inflammatory response, others use the intestine as a portal of entry to initiate a systemic infection. Considerable progress has been made in understanding bacterial invasion and dissemination strategies, as well as the nature of the Salmonella-specific immune response to oral infection. Innate and adaptive immunity are rapidly initiated after oral infection, but these effector responses can also be hindered by bacterial evasion strategies. Furthermore, although Salmonella resides within intramacrophage phagosomes, recent studies have highlighted a surprising collaboration of CD4 Th1, Th17, and B-cell responses in mediating resistance to Salmonella infection.

Indexed as

Adaptive ImmunityAnimalsDisease Models, AnimalHumansImmunity, InnateMiceMucous MembraneSalmonellaSalmonella Infections

Identifiers

PMID21307847
PMCPMC4084725
OpenAlexW2026950156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.