ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders.Journal of magnetic resonance imaging : JMRI · 2026Review
- Translational In Vivo Assays in Behavioral Biology.Annual review of pharmacology and toxicology · 2024Review
- Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition.Biological psychiatry · 2021Article
- Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates.Translational psychiatry · 2020Article
- Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates.Nature communications · 2019Article
- Areal differences in depth cue integration between monkey and human.PLoS biology · 2019Article
- The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2018Review
- The Prediction of Impact of a Looming Stimulus onto the Body Is Subserved by Multisensory Integration Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Tactile representation of the head and shoulders assessed by fMRI in the nonhuman primate.Journal of neurophysiology · 2016Article
- Data collection and analysis strategies for phMRI.Neuropharmacology · 2014Review
- The retinotopic organization of macaque occipitotemporal cortex anterior to V4 and caudoventral to the middle temporal (MT) cluster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Probabilistic and single-subject retinotopic maps reveal the topographic organization of face patches in the macaque cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neuroimaging in Alcohol and Drug Dependence.Current behavioral neuroscience reports · 2014Article
- Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment.Frontiers in behavioral neuroscience · 2014Article
- Investigation of cross-species translatability of pharmacological MRI in awake nonhuman primate - a buprenorphine challenge study.PloS one · 2014Article
- Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals.Biological psychiatry · 2013Article
- Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles.NMR in biomedicine · 2013Review
- Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates.Current opinion in neurobiology · 2013Article
- A receptor-based model for dopamine-induced fMRI signal.NeuroImage · 2013Article
- Brain activation and neurochemistry.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Disparities in cocaine-induced neurochemical and metabolic responses between human beings and rodents motivate the use of non-human primates (NHP) to model consequences of repeated cocaine exposure in human subjects. To characterize the functional response to cocaine infusion in NHP brain, we employed contrast-enhanced fMRI during both non-contingent injection of drug and self-administration of cocaine in the magnet. Cocaine robustly decreased cerebral blood volume (CBV) throughout basal ganglia and motor/pre-motor cortex and produced subtle functional inhibition of prefrontal cortex. No brain regions exhibited significant elevation of CBV in response to cocaine challenge. Theses effects in NHP brain are opposite in sign to the cocaine-induced fMRI response in rats, but consistent with previous measurements in NHP based on glucose metabolism. Because the striatal ratio of D2 to D1 receptors is larger in human beings and NHP than rats, we hypothesize that the inhibitory effects of D2 receptor binding dominate the functional response in primates, whereas excitatory D1 receptor stimulation predominates in the rat. If the NHP accurately models the human response to cocaine, downregulation of D2 receptors in human cocaine-abusing populations can be expected to blunt cocaine-induced functional responses, contributing to the weak and variable fMRI responses reported in human basal ganglia following cocaine infusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.