ReviewJournal of investigative medicine : the official publication of the American Federation for Clinical Research2011
Molecular mechanism of vitamin D in the cardiovascular system.
Review in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis.Microbial pathogenesis · 2020Pooled it
- The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Vitamin D and Lung Outcomes in Elderly COVID-19 Patients.Nutrients · 2021Trial
- Determining correlation between changes in blood pressure and vitamin D levels: Analyzing influencing factors in hypertensive adults at Family Medicine Clinics.Journal of family medicine and primary care · 2025Article
- Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy.Antioxidants (Basel, Switzerland) · 2023Review
- Impact of Vitamin D Supplementation on the Clinical Outcomes and Epigenetic Markers in Patients with Acute Coronary Syndrome.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency.Endocrine connections · 2022Review
- Correlation analysis between vitamin A, D, and E status with altitude, seasonal variation, and other factors, among children aged 0-6 years in a Chinese population living in the Tibetan plateau of Ganzi prefecture.Journal of clinical laboratory analysis · 2022Article
- Review
- Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection.Protein science : a publication of the Protein Society · 2021Review
- Could Vitamin D Be Effective in Prevention of Preeclampsia?Nutrients · 2021Review
- New Roles for Vitamin D Superagonists: From COVID to Cancer.Frontiers in endocrinology · 2021Review
- Review on COVID-19 Etiopathogenesis, Clinical Presentation and Treatment Available with Emphasis on ACE2.Indian journal of clinical biochemistry : IJCB · 2021Review
- MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.European journal of endocrinology · 2020Review
- Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19?The American journal of the medical sciences · 2020Review
- A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.Reviews in medical virology · 2020Review
- Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population.BMC public health · 2020Article
- Association between vitamin D and hypertension in people coming for health check up to a tertiary care centre in South India.Journal of family medicine and primary care · 2019Article
- Association of Vitamin D Status with Chronic Disease Risk Factors and Cognitive Dysfunction in 50⁻70 Year Old Adults.Nutrients · 2019Article
- Vitamin D and cardiovascular disease prevention.Nature reviews. Cardiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Vitamin D deficiency is a global health problem that has various adverse consequences. Vitamin D is mainly synthesized in the skin by sunlight (UV light) irradiation; therefore, vitamin D status is influenced by geographic locations, seasonal changes, and skin pigmentations. The kidney is involved in the biosynthesis of 1,25-dihydroxyvitamin D and the reuptake of filtered 25-hydroxyvitamin D from the proximal tubules, thus, vitamin D deficiency is highly prevalent in patients with kidney disease who have renal insufficiency. There is a growing body of epidemiological and clinical evidence in the literature that links vitamin D deficiency to cardiovascular disease. The discovery of the vitamin D hormone functioning as an endocrine inhibitor of the renin-angiotensin system provides an explanation for this association. This review will discuss the mechanism underlying the connection between vitamin D and cardiovascular disease and its physiological and therapeutic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.