ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Renovascular disease, microcirculation, and the progression of renal injury: role of angiogenesis.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Article
- Super-Resolution Ultrasound Imaging of Renal Vascular Alterations in Zucker Diabetic Fatty Rats during the Development of Diabetic Kidney Disease.Diagnostics (Basel, Switzerland) · 2023Article
- The therapeutic potential of Camel Wharton jelly mesenchymal stem cells (CWJ-MSCs) in canine chronic kidney disease model.Stem cell research & therapy · 2022Article
- Inflammation and Oxidative Damage in Ischaemic Renal Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney.Stem cell research · 2020Article
- Targeting angiogenesis and lymphangiogenesis in kidney disease.Nature reviews. Nephrology · 2020Review
- Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- The Kidney Dysfunction Epidemic, Part 2: Intervention.Integrative medicine (Encinitas, Calif.) · 2016Article
- Chronic renal ischemia in humans: can cell therapy repair the kidney in occlusive renovascular disease?Physiology (Bethesda, Md.) · 2015Review
- Mitochondria: a pathogenic paradigm in hypertensive renal disease.Hypertension (Dallas, Tex. : 1979) · 2015Review
- Tipping the balance from angiogenesis to fibrosis in CKD.Kidney international supplements · 2014Review
- Potential approaches to reverse or repair renal fibrosis.Nature reviews. Nephrology · 2014Review
- Remnant nephron physiology and the progression of chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Darkness at the end of the tunnel: poststenotic kidney injury.Physiology (Bethesda, Md.) · 2013Review
- Renal vascular structure and rarefaction.Comprehensive Physiology · 2013Review
- Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.Stem cell research & therapy · 2013Review
- Cell-Based Therapies as an Adjunct to Revascularization in Experimental Atherosclerotic Reno Vascular Disease.Journal of clinical & experimental cardiology · 2012Article
- Addition of endothelial progenitor cells to renal revascularization restores medullary tubular oxygen consumption in swine renal artery stenosis.American journal of physiology. Renal physiology · 2012Article
- The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stress.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Emerging evidence supports the pivotal role of renal microvascular disease as a determinant of tubulo-interstitial and glomerular fibrosis in chronic kidney disease. An intact microcirculation is vital to restore blood flow to the injured tissues, which is a crucial step to achieve a successful repair response. The purpose of this review is to discuss the impact and mechanisms of the functional and structural changes of the renal microvascular network, as well as the role of these changes in the progression and irreversibility of renal injury. Damage of the renal microcirculation and deterioration of the angiogenic response may constitute early steps in the complex pathways involved in progressive renal injury. There is limited but provocative evidence that stimulation of vascular proliferation and repair may stabilize renal function and slow the progression of renal disease. The feasibility of novel potential therapeutic interventions for stabilizing the renal microvasculature is also discussed. Targeted interventions to enhance endogenous renoprotective mechanisms focused on the microcirculation, such as cell-based therapy or the use of angiogenic cytokines have shown promising results in some experimental and clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.