ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Salivary glands act as mucosal inductive sites via the formation of ectopic germinal centers after site-restricted MCMV infection.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Assessment of Anti-M3R antibody in patients with oral lichen planus complaining of xerostomia: a preliminary study.BMC oral health · 2026Article
- Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands.PLoS computational biology · 2024Article
- Vitamin A Positively Correlates with Secretory Immunoglobulin A: A Cross-Sectional Study in Omicron COVID-19 Outpatients.Journal of clinical medicine · 2024Article
- CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands.Pathogens (Basel, Switzerland) · 2021Review
- Lymph node stromal cells: cartographers of the immune system.Nature immunology · 2020Review
- Salivary gland immunizationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse.Frontiers in immunology · 2018Article
- Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells.Frontiers in immunology · 2018Review
- Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.Frontiers in immunology · 2017Review
- The salivary gland as a target for enhancing immunization response.Tropical diseases, travel medicine and vaccines · 2017Review
- Potential of Cells and Cytokines/Chemokines to Regulate Tertiary Lymphoid Structures in Human Diseases.Immune network · 2016Review
- Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity.Journal of virology · 2016Article
- Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues.Immunology · 2016Review
- Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together.Frontiers in immunology · 2016Review
- Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.The Journal of experimental medicine · 2015Article
- Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Ectopic lymphoid-like structures in infection, cancer and autoimmunity.Nature reviews. Immunology · 2014Review
- Protective MCMV immunity by vaccination of the salivary gland via Wharton's duct: replication-deficient recombinant adenovirus expressing individual MCMV genes elicits protection similar to that of MCMV.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Systemic immune response development in Albino rats after retrograde instillation of COVID-19 vaccine to submandibular salivary gland: An experimental study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We investigated the hypothesis that salivary gland inoculation stimulates formation of ectopic germinal centers (GCs), transforming the gland into a mucosal inductive site. Intraglandular infection of mice with murine cytomegalovirus (MCMV; control: UV-inactivated MCMV) induces salivary gland ectopic follicles comprising cognate interactions between CD4(+) and B220(+) lymphocytes, IgM(+) and isotype-switched IgG(+) and IgA(+) B cells, antigen presenting cells, and follicular dendritic cells. B cells coexpressed the GC markers GCT (57%) and GL7 (52%), and bound the lectin peanut agglutinin. Lymphoid follicles were characterized by a 2- to 3-fold increase in mRNA for CXCL13 (lymphoid neogenesis), syndecan-1 (plasma cells), Blimp-1 (plasma cell development/differentiation), and a 2- to 6-fold increase for activation-induced cytidine deaminase, PAX5, and the nonexcised rearranged DNA of an IgA class-switch event, supporting somatic hypermutation and class-switch recombination within the salivary follicles. Intraglandular inoculation also provided protection against a systemic MCMV challenge, as evidenced by decreased viral titers (10(5) plaque-forming units to undetectable), and restoration of normal salivary flow rates from a 6-fold decrease. Therefore, these features suggest that the salivary gland participates in oral mucosal immunity via generation of ectopic GCs, which function as ectopic mucosal inductive sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.