ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Racial variation in umbilical cord blood leptin concentration in male babies.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis.British journal of cancer · 2016Pooled it
- Maternal and fetal factors affecting cord plasma leptin and adiponectin levels and their ratio in preterm and term newborns: New insight on fetal origins of metabolic dysfunction.Precision nutrition · 2022Article
- Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations.Cancer causes & control : CCC · 2018Article
- Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?Prostate cancer · 2016Article
- Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: a prospective study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans.Scientific reports · 2013Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWe hypothesize that racial differences in utero contribute to the racial disparity in prostate cancer risk. Leptin is a candidate for evaluating this hypothesis because it influences fetal development and newborn growth.
methodsWe measured leptin concentration by ELISA in venous cord blood collected from 70 African-American and 37 white male full-term babies. We measured sex steroid hormones and insulin-like growth factor (IGF) axis concentrations previously. Separately by race, we calculated the geometric mean leptin concentration and estimated the geometric mean adjusted for birth and placental weights, mother's age and parity, time of day and season of birth, and sex steroid hormone and IGF axis concentrations by linear regression.
resultsLeptin was positively correlated with birth (r = 0.34) and placental (r = 0.25) weights, IGF-1 (r = 0.21), and IGF binding protein-3 (r = 0.29) adjusting for race. Unadjusted geometric mean leptin did not differ (P = 0.92) between African Americans (5,280 pg/mL; 95% CI: 4,322-6,451) and whites (5,187 pg/mL; 95% CI: 3,938-6,832). Adjusted geometric mean leptin was nonstatistically significantly higher (P = 0.15) in African Americans (5,954 pg/mL; 95% CI: 4,725-7,502) than in whites (4,133 pg/mL; 95% CI: 2,890-5,910).
conclusionWe observed a nonsignificantly higher adjusted cord blood leptin concentration in African-American male babies than in white male babies, although unadjusted levels were similar. IMPACT: These findings do not support the hypothesis that leptin level in utero contributes to the racial disparity in prostate cancer risk in adulthood.
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