ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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Who cites it
67 citing papers in PubMed.
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- TCF3 and ID3 Regulate TSPAN32 Expression in Burkitt Lymphoma.Scandinavian journal of immunology · 2025Article
- Inferring Covariance Structure from Multiple Data Sources via Subspace Factor Analysis.Journal of the American Statistical Association · 2025Article
- Asparagine availability controls germinal center B cell homeostasis.Science immunology · 2024Article
- BatchFLEX: feature-level equalization of X-batch.Bioinformatics (Oxford, England) · 2024Article
- A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.Cell stem cell · 2024Article
- Genomic view of the origins of cell-mediated immunity.Immunogenetics · 2023Article
- Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells.Science advances · 2023Article
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- The endogenous repertoire harbors self-reactive CD4Nature immunology · 2023Article
- The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development.Nucleic acids research · 2022Article
- Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy.Cancer discovery · 2022Article
- Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids.Cellular & molecular immunology · 2021Review
- Cross-tissue organization of the fibroblast lineage.Nature · 2021Article
- Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy.Nature cancer · 2021Article
- Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma.Frontiers in pharmacology · 2021Article
- Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.Experimental hematology · 2020Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
T and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches of adaptive immunity. Although originating from a common precursor, they play very different roles: T cells contribute to and drive cell-mediated immunity, whereas B cells secrete Abs. Because of their functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal cell types with which to understand how functional differences are encoded at the transcriptional level. Although there has been a great deal of interest in defining regulatory factors that distinguish T and B cells, a truly genomewide view of the transcriptional differences between these two cells types has not yet been taken. To obtain a more global perspective of the transcriptional differences underlying T and B cells, we exploited the statistical power of combinatorial profiling on different microarray platforms, and the breadth of the Immunological Genome Project gene expression database, to generate robust differential signatures. We find that differential expression in T and B cells is pervasive, with the majority of transcripts showing statistically significant differences. These distinguishing characteristics are acquired gradually, through all stages of B and T differentiation. In contrast, very few T versus B signature genes are uniquely expressed in these lineages, but are shared throughout immune cells.
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