ArticleClinical and vaccine immunology : CVI2011
Needleless vaccine delivery using micro-shock waves.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 65 citations in OpenAlex.
- Optothermal Needle-Free Injection of Vaterite Nanocapsules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A microexplosive shockwave-based drug delivery microsystem for treating hard-to-reach areas in the human body.Microsystems & nanoengineering · 2022Article
- Shock wave impact on the viability of MDA-MB-231 cells.PloS one · 2020Article
- Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot.Science advances · 2020Article
- Stimulation of angiogenesis using single-pulse low-pressure shock wave treatment.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Enhancement of the Effectiveness of Extracorporeal Shock Wave Therapy with Topical Corticosteroid in Treatment of Chronic Plantar Fasciitis: A Randomized Control Clinical Trial.Advanced biomedical research · 2018Article
- Mechanism of transformation in Mycobacteria using a novel shockwave assisted technique driven by in-situ generated oxyhydrogen.Scientific reports · 2017Article
- Optimization of a Diaphragm for a Micro-Shock Tube-Based Drug Delivery Method.Bioengineering (Basel, Switzerland) · 2017Article
- Insights into the mechanism of a novel shockwave-assisted needle-free drug delivery device driven by in situ-generated oxyhydrogen mixture which provides efficient protection against mycobacterial infections.Journal of biological engineering · 2017Article
- Successful treatment of biofilm infections using shock waves combined with antibiotic therapy.Scientific reports · 2015Article
- Needle free injection technology: A complete insight.International journal of pharmaceutical investigationReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shock waves are one of the most efficient mechanisms of energy dissipation observed in nature. In this study, utilizing the instantaneous mechanical impulse generated behind a micro-shock wave during a controlled explosion, a novel nonintrusive needleless vaccine delivery system has been developed. It is well-known that antigens in the epidermis are efficiently presented by resident Langerhans cells, eliciting the requisite immune response, making them a good target for vaccine delivery. Unfortunately, needle-free devices for epidermal delivery have inherent problems from the perspective of the safety and comfort of the patient. The penetration depth of less than 100 μm in the skin can elicit higher immune response without any pain. Here we show the efficient utilization of our needleless device (that uses micro-shock waves) for vaccination. The production of liquid jet was confirmed by high-speed microscopy, and the penetration in acrylamide gel and mouse skin was observed by confocal microscopy. Salmonella enterica serovar Typhimurium vaccine strain pmrG-HM-D (DV-STM-07) was delivered using our device in the murine salmonellosis model, and the effectiveness of the delivery system for vaccination was compared with other routes of vaccination. Vaccination using our device elicits better protection and an IgG response even at a lower vaccine dose (10-fold less) compared to other routes of vaccination. We anticipate that our novel method can be utilized for effective, cheap, and safe vaccination in the near future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.