Evidence map›Paper›PMID 21307197›Full record

ArticleJournal of virology2011

Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome contains a duplication of a long unique-region fragment within the terminal repeat region.

Yuri Yakushko, Christian Hackmann, Thomas Günther, Jessica Rückert, Marc Henke, Lars Koste, Khaled Alkharsah, Jens Bohne, Adam Grundhoff, Thomas F Schulz and 1 more

Abstract read
In one paragraph

Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Trial
  2. Genome-Wide Analysis IdentifiesCurrent issues in molecular biology · 2026
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  4. Review
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  8. The mRNA (New York, N.Y.) · 2021
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuri YakushkoInstitute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
Christian Hackmann
Thomas Günther
Jessica Rückert
Marc Henke
Lars Koste
Khaled Alkharsah
Jens Bohne
Adam Grundhoff
Thomas F Schulz
Cornelia Henke-Gendo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Use of the Kaposi's sarcoma-associated herpesvirus (KSHV) bacterial artificial chromosome 36 (KSHV-BAC36) genome permits reverse genetics approaches to study KSHV biology. While sequencing the complete KSHV-BAC36 genome, we noted a duplication of a 9-kb fragment of the long unique region in the terminal repeat region. This duplication covers a part of open reading frame (ORF) 19, the complete ORFs 18, 17, 16, K7, K6, and K5, and the putative ORF in the left origin of lytic replication, and it contains the BAC cassette. This observation needs to be kept in mind if viral genes located within the duplicated region are to be mutated in KSHV-BAC36.

Indexed as

Chromosomes, Artificial, BacterialSegmental Duplications, GenomicTerminal Repeat SequencesDNA, ViralHerpesvirus 8, HumanMolecular Sequence DataOpen Reading FramesSequence Analysis, DNADNA, Viral

Identifiers

PMID21307197
PMCPMC3126277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.