ArticleThe Journal of clinical endocrinology and metabolism2011
Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Magnitude and Timing of the Postprandial Inflammatory Response to a High-Fat Meal in Healthy Adults: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- The relationship between gestational diabetes mellitus and interleukin 1beta gene polymorphisms in southwest of China.Medicine · 2020Observational
- Quantile-dependent expressivity of postprandial lipemia.PloS one · 2020Article
- An update on the genetics of hyperuricaemia and gout.Nature reviews. Rheumatology · 2018Review
- Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer.Journal of pain and symptom management · 2018Article
- Association between IL-1 gene polymorphisms and tuberculosis susceptibility in the Chinese Tibetan population.International journal of clinical and experimental pathology · 2018Article
- Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.PloS one · 2016Article
- Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease.Lipids in health and disease · 2015Article
- Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout.Arthritis research & therapy · 2015Article
- Genetic variation in Tanis was associated with elevating plasma triglyceride level in Chinese nondiabetic subjects.Lipids in health and disease · 2013Article
- Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.Journal of lipid research · 2013Article
- Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populations.PloS one · 2012Article
- More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism.The Journal of clinical endocrinology and metabolism · 2011Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
contextIL1b (IL1B or IL1β), a key modulator of the immune response, exerts its functions mainly via IL6 regulation. Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility.
objectiveWe evaluated the influence of a genetic variant located in the promoter region of IL1B (-1473G/C) on fasting and postprandial lipids and IL6. DESIGN, SETTING, AND
participantsA total of 477 people over age 65 yr were genotyped for IL1B -1473G/C, and we evaluated fasting lipids depending on genotype. Then, 88 healthy young men were also genotyped and were fed a saturated fatty acid-rich meal. Serial blood samples were drawn for 11 h after the meal, and lipid fractions and IL6 were assayed. MAIN OUTCOME AND
interventionsFasting lipids were studied in the aged persons. Fasting and postprandial measurements of lipids and IL6 were performed in the healthy young men.
resultsIn the aged persons, CC subjects (minor allele homozygotes) showed higher triglyceride (P = 0.002) and cholesterol (P = 0.011) levels. Healthy young male carriers of the minor C allele showed higher postprandial triglycerides (P = 0.037), and those carried into large triglyceride-rich lipoproteins (P = 0.004). In addition, they showed higher postprandial IL6 concentrations (P = 0.008).
conclusionsOur work shows that inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL gene variant have altered lipid metabolism. To reinforce these gene-phenotype findings, IL6 (the natural effector of IL1B) was increased in these persons.
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