ArticleAmerican journal of physiology. Renal physiology2011
p53 target Siva regulates apoptosis in ischemic kidneys.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Impact of methimazole-induced hypothyroidism on postnatal swine.Physiological reports · 2024Article
- Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expression.Frontiers in immunology · 2024Article
- Proximal TubularInternational journal of molecular sciences · 2023Article
- Porcine reproductive and respiratory virus 2 infection of the fetus results in multi-organ cell cycle suppression.Veterinary research · 2022Article
- Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury.Frontiers in physiology · 2022Article
- Molecular characterization, expression, and apoptosis regulation of siva1 in protogynous hermaphrodite fish ricefield eel (Monopterus albus).Fish physiology and biochemistry · 2021Article
- Shen Shuai II Recipe Attenuates Apoptosis in 5/6 Renal Ablation/Infarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis.Oxidative medicine and cellular longevity · 2020Article
- Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury.Kidney international reports · 2017Article
- Mitogen-Activated Protein Kinase 14 Promotes AKI.Journal of the American Society of Nephrology : JASN · 2017Article
- Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- TIGAR regulates glycolysis in ischemic kidney proximal tubules.American journal of physiology. Renal physiology · 2015Article
- Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury.Journal of the American Society of Nephrology : JASN · 2014Article
- Tubular p53 regulates multiple genes to mediate AKI.Journal of the American Society of Nephrology : JASN · 2014Article
- Renal nerves drive interstitial fibrogenesis in obstructive nephropathy.Journal of the American Society of Nephrology : JASN · 2013Article
- Mouse model of ischemic acute kidney injury: technical notes and tricks.American journal of physiology. Renal physiology · 2012Review
- Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism.Cell death and differentiation · 2012Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of p53 in inducing apoptosis following acute kidney injury is well-established; however, the molecular mechanisms remain largely unknown. We report here that the p53 proapoptotic target Siva and its receptor CD27, a member of the tumor necrosis factor receptor family, are upregulated following renal ischemia-reperfusion injury (IRI). Inhibition of Siva using antisense oligonucleotides conferred functional and morphological protection, and it prevented apoptosis postrenal IRI in mice. Renal IRI in CD27-deficient mice displayed functional protection and partial inhibition of apoptosis, suggesting an incomplete role for CD27 in Siva-mediated apoptosis. To further elucidate mechanisms by which Siva elicits apoptosis, in vitro studies were performed. In Siva-transfected LLC-PK(1)cells, Siva is persistently expressed in the nucleus at 3 h onwards and its translocation to mitochondria and the plasma membrane occurred at 6 h. Moreover, Siva overexpression induced mitochondrial permeability, cytochrome c release, caspase-8 and -9 activation, translocation of apoptosis-inducing factor (AIF) to the nucleus, and apoptosis. Inhibition of Siva in ischemic kidneys prevented mitochondrial release of cytochrome c and AIF. These data indicate that Siva function is pivotal in regulating apoptosis in the pathology of renal IRI. Targeting Siva may offer a potential therapeutic strategy for renal IRI.
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