ArticleDiabetes2011
Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals.Science translational medicine · 2021Trial
- Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice.The Journal of veterinary medical science · 2023Article
- Ultrasound Imaging of Pancreatic Perfusion Dynamics Predicts Therapeutic Prevention of Diabetes in Preclinical Models of Type 1 Diabetes.Ultrasound in medicine & biology · 2022Article
- VEGF-A and blood vessels: a beta cell perspective.Diabetologia · 2019Review
- Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes.Journal of ophthalmology · 2019Article
- Human urine-derived stem cells play a novel role in the treatment of STZ-induced diabetic mice.Journal of molecular histology · 2018Article
- Type 1 diabetes.Lancet (London, England) · 2018Review
- Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models.Nature communications · 2018Article
- β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.Cell metabolism · 2017Article
- Diabetic macular edema, retinopathy and age-related macular degeneration as inflammatory conditions.Archives of medical science : AMS · 2016Article
- Life and death of β cells in Type 1 diabetes: A comprehensive review.Journal of autoimmunity · 2016Review
- Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes.PloS one · 2016Article
- New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.Diabetologia · 2015Review
- Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset.IUBMB life · 2015Article
- Potential role of polyunsaturated fatty acids in diabetic retinopathy.Archives of medical science : AMS · 2014Article
- 3-Dimensional histological reconstruction and imaging of the murine pancreas.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Pancreatic duct cells as a source of VEGF in mice.Diabetologia · 2014Article
- Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes.Diabetologia · 2014Article
- Omeprazole and PGC-formulated heparin binding epidermal growth factor normalizes fasting blood glucose and suppresses insulitis in multiple low dose streptozotocin diabetes model.Pharmaceutical research · 2013Article
- Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.Diabetes · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveβ-Cell and islet endothelial cell destruction occurs during the progression of type 1 diabetes, but, paradoxically, β-cell proliferation is increased during this period. Altered glucose tolerance may affect β-cell mass and its association with endothelial cells. Our objective was to study the effects of glucose and inflammation on islet vascularity and on β function, mass, and insulin in immunologically tolerant anti-CD3 monoclonal antibody (mAb)-treated and prediabetic NOD mice. RESEARCH DESIGN AND
methodsThe effects of phloridzin or glucose injections on β-cells and endothelial cells were tested in prediabetic and previously diabetic NOD mice treated with anti-CD3 mAbs. Glucose tolerance, immunofluorescence staining, and examination of islet cultures ex vivo were evaluated.
resultsIslet endothelial cell density decreased in NOD mice and failed to recover after anti-CD3 mAb treatment despite baseline euglycemia. Glucose treatment of anti-CD3 mAb-treated mice showed increased islet vascular density and increased insulin content, which was associated with improved glucose tolerance. The increase in the vascular area was dependent on islet inflammation. Increased islet endothelial cell density was associated with increased production of vascular endothelial growth factor (VEGF) by islets from NOD mice. This response was recapitulated ex vivo by the transfer of supernatants from NOD islets cultured in high-glucose levels.
conclusionsOur results demonstrate a novel role for glucose and inflammation in the control of islet vasculature and insulin content of β-cells in prediabetic and anti-CD3-treated NOD mice. VEGF production by the islets is affected by glucose levels and is imparted by soluble factors released by inflamed islets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.