ArticleJournal of psychiatric research2011
Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia.
Article in Journal of psychiatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Brain microstructural alterations in COVID-19: a systematic review of diffusion weighted imaging studies.Brain imaging and behavior · 2026Pooled it
- The Role of White Matter in the Neural Control of Swallowing: A Systematic Review.Frontiers in human neuroscience · 2021Pooled it
- Schizophrenia symptomatic associations with diffusion tensor imaging measured fractional anisotropy of brain: a meta-analysis.Neuroradiology · 2017Pooled it
- Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic Treatment.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Substance use involvement moderates the effect of cortisol response on white-matter microstructure longitudinally.Dialogues in clinical neuroscience · 2026Article
- Disentangling white matter correlates of symptom severity and general impairment in early psychosis.Molecular psychiatry · 2026Article
- Brain imaging-derived phenotypes influence risk of bipolar disorder: comprehensive exposome-wide association and wide-angled genetic analyses.BMC medicine · 2026Article
- Diffusion tensor imaging of cerebellar peduncles and association tracts in a case of primary complete callosal agenesis.Brain structure & function · 2026Article
- Alzheimer-related individual factors modulate effects of transcranial direct current stimulation strength on white matter integrity in mild cognitive impairment.Scientific reports · 2025Article
- Menstrual cycle-driven hormone concentrations co-fluctuate with white and gray matter architecture changes across the whole brain.Human brain mapping · 2024Article
- TractGeoNet: A geometric deep learning framework for pointwise analysis of tract microstructure to predict language assessment performance.Medical image analysis · 2024Article
- Estimating the prevalence of Non-Verbal Learning Disability (NVLD) from the ABCD sample.Scientific reports · 2024Article
- Peak width of skeletonized mean diffusivity as a neuroimaging biomarker in first-episode schizophrenia.Frontiers in neuroscience · 2024Article
- Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis.AJNR. American journal of neuroradiology · 2023Article
- Profiling intra- and inter-individual differences in brain development across early adolescence.NeuroImage · 2023Article
- A review of multi-modal magnetic resonance imaging studies on perimenopausal brain: a hint towards neural heterogeneity.European radiology · 2023Review
- Article
- Estimation for the bivariate quantile varying coefficient model with application to diffusion tensor imaging data analysis.Biostatistics (Oxford, England) · 2023Article
- Activation of the left medial temporal gyrus and adjacent brain areas during affective theory of mind processing correlates with trait schizotypy in a nonclinical population.Social cognitive and affective neuroscience · 2023Article
- Structural and connectivity parameters reveal spared connectivity in young patients with non-progressive compared to slow-progressive cerebellar ataxia.Frontiers in neurology · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The goals of this study were to first determine whether the fractional anisotropy (FA) and mean diffusivity (MD) of major white matter pathways associate with schizophrenia, and secondly to characterize the extent to which differences in these metrics might reflect a genetic predisposition to schizophrenia. Differences in FA and MD were identified using a comprehensive atlas-based tract mapping approach using diffusion tensor imaging and high-resolution structural data from 35 patients, 28 unaffected first-degree relatives of patients, 29 community controls, and 14 first-degree relatives of controls. Schizophrenia patients had significantly higher MD in the following tracts compared to controls: the right anterior thalamic radiations, the forceps minor, the bilateral inferior fronto-occipital fasciculus (IFO), the temporal component of the left superior longitudinal fasciculus (tSLF), and the bilateral uncinate. FA showed schizophrenia effects and a linear relationship to genetic liability (represented by schizophrenia patients, first-degree relatives, and controls) for the bilateral IFO, the left inferior longitudinal fasciculus (ILF), and the left tSLF. Diffusion tensor imaging studies have previously identified white matter abnormalities in all three of these tracts in schizophrenia; however, this study is the first to identify a significant genetic liability. Thus, FA of these three tracts may serve as biomarkers for studies seeking to identify how genes influence brain structure predisposing to schizophrenia. However, differences in FA and MD in frontal and temporal white matter pathways may be additionally driven by state variables that involve processes associated with the disease.
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