ArticleAddiction (Abingdon, England)2011
Empirically derived subtypes of opioid use and related behaviors.
Article in Addiction (Abingdon, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes.Addiction biology · 2020Trial
- Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.Biological psychiatry · 2023Article
- Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.The Journal of pharmacology and experimental therapeutics · 2022Article
- The Identification of Subphenotypes and Associations with Health Outcomes in Patients with Opioid-Related Emergency Department Encounters Using Latent Class Analysis.International journal of environmental research and public health · 2022Article
- Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations.Translational psychiatry · 2022Article
- Contextual risk among adolescents receiving opioid prescriptions for acute pain in pediatric ambulatory care settings.Addictive behaviors · 2020Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Article
- Unique aspects of impulsive traits in substance use and overeating: specific contributions of common assessments of impulsivity.The American journal of drug and alcohol abuse · 2014Article
- Multi-view singular value decomposition for disease subtyping and genetic associations.BMC genetics · 2014Article
- Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Multiview comodeling to improve subtyping and genetic association of complex diseases.IEEE journal of biomedical and health informatics · 2014Article
- Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction.PloS one · 2013Article
- Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.Addictive behaviors · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimsTo identify and validate homogeneous subtypes of opioid use and related behaviors.
designFamily-based and case-control genetic studies of opioid and/or cocaine dependence. SETTINGS: Clinical and general community samples from Connecticut, Massachusetts, Pennsylvania and South Carolina.
participantsA total of 4061 individuals (2003 individuals from 835 families and 2058 unrelated individuals) recruited to participate in genetic studies. MEASUREMENTS: The computer-assisted Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) was used to assess participants' demographics, medical history, substance use behaviors and disorders and other psychiatric disorders.
findingsFive homogeneous subtypes were identified, which differed on opioid-related measures, demographics and prevalence rates of substance use and psychiatric disorders. Heritability estimates for the two most severely affected subtypes exceeded 0.60.
conclusionsAn empirical approach based on opioid use and related behaviors can yield homogeneous subtypes that could be of value in gene finding for opioid dependence.
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