ArticleCancer science2011
ABO blood group alleles and the risk of pancreatic cancer in a Japanese population.
Article in Cancer science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Association of ABO polymorphisms and pancreatic Cancer/ Cardiocerebrovascular disease: a meta-analysis.BMC medical genetics · 2020Pooled it
- ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis.American journal of epidemiology · 2013Pooled it
- A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.Nature genetics · 2012Pooled it
- Diabetes mellitus, ABO Blood groups, and biochemical correlates in pancreatic cancer- A retrospective study from Jeddah.Journal of family medicine and primary care · 2026Article
- ABO gene polymorphisms: a molecular bridge linking disease susceptibility to therapeutic outcomes.Frontiers in medicine · 2026Review
- Blood Group Antigen Expression in Blood and Tumor in Relation to Survival Outcomes in Resected Pancreatic Cancer, Overall and by Adjuvant Chemotherapy Regimens.Annals of surgical oncology · 2025Article
- Prognostic value of ABO blood groups in upfront operated pancreatic ductal adenocarcinomas.Langenbeck's archives of surgery · 2024Article
- ABO Blood Type and Clinical Characteristics Among Japanese Patients With Ulcerative Colitis.Cureus · 2024Article
- Association between ABO blood group/genotype and COVID-19 in a Japanese population.Annals of hematology · 2023Article
- Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients.Current urology · 2022Article
- ABO Blood Type and Risk of Peyronie's Disease in Japanese Males.The world journal of men's health · 2022Article
- ABO blood group system and risk of positive surgical margins in patients treated with robot-assisted radical prostatectomy: results in 1114 consecutive patients.Journal of robotic surgery · 2022Article
- Influence of Cancer Susceptibility Gene Mutations and ABO Blood Group of Pancreatic Cancer Probands on Concomitant Risk to First-Degree Relatives.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- A cross-population atlas of genetic associations for 220 human phenotypes.Nature genetics · 2021Article
- Is there an association between ABO blood types and depressive symptoms among Japanese healthcare workers during the COVID-19 pandemic?PloS one · 2021Article
- Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.Gut and liver · 2020Review
- ABO Blood Type and the Long-term Outcomes of Pancreatic Cancer.Internal medicine (Tokyo, Japan) · 2020Article
- A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men.BMC genomics · 2019Article
- Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health StudyAsian Pacific journal of cancer prevention : APJCP · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have investigated a possible association between the ABO blood group and the risk of pancreatic cancer (PC), but this association has not been fully evaluated in Asian populations. The present study aimed to assess the impact of genotype-derived ABO blood types, particularly ABO alleles, on the risk of PC in a Japanese population. We conducted a case-control study using 185 PC and 1465 control patients who visited Aichi Cancer Center in Nagoya, Japan. Using rs8176719 as a marker for the O allele, and rs8176746 and rs8176747 for the B allele, all participants' two ABO alleles were inferred. The impact of ABO blood type on PC risk was examined by multivariate analysis, with adjustment for potential confounders to estimate odds ratios (OR) and 95% confidence intervals (CI). An increased risk of PC was observed with the addition of any non-O allele (trend P = 0.012). Compared with subjects with the OO genotype, those with AO and BB genotypes had significantly increased OR of 1.67 (CI, 1.08-2.57) and 3.28 (CI, 1.38-7.80), respectively. Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele. In conclusion, this case-control study showed a statistically significant association between ABO blood group and PC risk in a Japanese population. Further studies are necessary to define the mechanisms by which the ABO gene or closely linked genetic variants influence PC risk.
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