ArticleBritish journal of clinical pharmacology2011
Adherence to national guidelines for initiation of antiretroviral regimens in HIV patients: a Danish nationwide study.
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pneumocystis Pneumonia-Is it Still a Threat Among People With Human Immunodeficiency Virus (HIV)? A Danish HIV Cohort Study.Open forum infectious diseases · 2025Article
- HIV treatment regimens and adherence to national guidelines in Australia: an analysis of dispensing data from the Australian pharmaceutical benefits scheme.BMC public health · 2019Article
- Article
- The effect of adherence to guidelines for initial antiretroviral therapy on 1-year outcomes: a French cohort study.BMC infectious diseases · 2014Article
- Modeling the dissemination and uptake of clinical trials results.Research Evaluation · 2013Article
- Impact of gender on response to highly active antiretroviral therapy in HIV-1 infected patients: a nationwide population-based cohort study.BMC infectious diseases · 2012Article
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Authors and funding
8 authors.
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Abstract
aimTo determine the adherence to the national guidelines for start of highly active antiretroviral treatment (HAART) in HIV infected patients.
methodsWe used a Danish nationwide cohort of HIV infected patients to calculate the fraction of patients who in the period 1997-2006 started HAART according to the guidelines from The Danish Society of Infectious Diseases. We used Kaplan-Meier tables to estimate time from fulfilling the criteria for start of HAART to initiation of the treatment. Cox regression and logistic regression was used to identify risk factors for delayed initiation of treatment and chance of being included in clinical trials.
resultsThe study included 3223 patients, 74% of whom initiated HAART in the study period. Ninety-four% fulfilled the criteria for start of HAART, with minor differences over calendar periods. Ninety-four% initiated a recommended regimen or were included in a clinical trial. Intravenous drug use predicted initiation of a non-recommended regimen and delay in start of HAART, while non-Caucasians were less likely to be included in clinical trials.
conclusionsIn a Western world setting, the adherence to national guidelines for start of HAART can be high. We suggest that simplicity of the guidelines, centralization of treatment and involvement of local clinicians in the development of guidelines are of major importance for high adherence to treatment guidelines.
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