ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse.Genes · 2022Pooled it
- Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population.Translational psychiatry · 2021Pooled it
- Article
- Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Characterisation of age and polarity at onset in bipolar disorder.The British journal of psychiatry : the journal of mental science · 2021Article
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.Bipolar disorders · 2019Article
- A Genome-Wide Search for Bipolar Disorder Risk Loci Modified by Mitochondrial Genome Variation.Molecular neuropsychiatry · 2018Article
- Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups.International journal of bipolar disorders · 2017Article
- Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.Bipolar disorders · 2015Article
- Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis.Journal of affective disorders · 2015Article
- New developments in the genetics of bipolar disorder.Current psychiatry reports · 2014Review
- Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.Bipolar disorders · 2014Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Clinical phenotype of bipolar disorder with comorbid binge eating disorder.Journal of affective disorders · 2013Article
- Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations.Discovery medicine · 2013Review
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: no consistent evidence for an association in the Nordic population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology.Biology of mood & anxiety disorders · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 11 institutions in 3 countries.
Funding
Abstract
Genome-wide association studies (GWAS) have identified several susceptibility loci for bipolar disorder (BP), most notably ANK3. However, most of the inherited risk for BP remains unexplained. One reason for the limited success may be the genetic heterogeneity of BP. Clinical sub-phenotypes of BP may identify more etiologically homogeneous subsets of patients, which can be studied with increased power to detect genetic variation. Here, we report on a mega-analysis of two widely studied sub-phenotypes of BP, age at onset and psychotic symptoms, which are familial and clinically significant. We combined data from three GWAS: NIMH Bipolar Disorder Genetic Association Information Network (GAIN-BP), NIMH Bipolar Disorder Genome Study (BiGS), and a German sample. The combined sample consisted of 2,836 BP cases with information on sub-phenotypes and 2,744 controls. Imputation was performed, resulting in 2.3 million SNPs available for analysis. No SNP reached genome-wide significance for either sub-phenotype. In addition, no SNP reached genome-wide significance in a meta-analysis with an independent replication sample. We had 80% power to detect associations with a common SNP at an OR of 1.6 for psychotic symptoms and a mean difference of 1.8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.