Evidence map›Paper›PMID 21305689›Full record

ReviewGenesis (New York, N.Y. : 2000)2011

The emerging face of primary cilia.

Norann A Zaghloul, Samantha A Brugmann

Open access · bronzeAbstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  7. Article
  8. Review
  9. Role of Primary Cilia in Bone and Cartilage.Journal of dental research · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Hedgehog Signaling and Embryonic Craniofacial Disorders.Journal of developmental biology · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Norann A ZaghloulDepartment of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Samantha A Brugmann
Cincinnati Children's Hospital Medical Center · USUniversity of Maryland, Baltimore · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
The role of primary cilia in craniofacial developmentR00DE019853 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2011 to 2013
$725k
Ciliary Regulation of Notch-based PhenotypesK01DK092402 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ZAGHLOUL, NORANN AMIR · 2011 to 2013
$338k
The role of primary cilia in craniofacial developmentK99DE019853 · NIDCR · STANFORD UNIVERSITY · PI BRUGMANN, SAMANTHA A · 2010 to 2010
$93k
NIDCR NIH HHS K99 DE019853NIDCR NIH HHS K99 DE019853-01NIDCR NIH HHS R00 DE019853NIDDK NIH HHS K01 DK092402NIDDK NIH HHS P30 DK079637
6 · The paper itself

Abstract

Primary cilia are microtubule-based organelles that serve as hubs for the transduction of various developmental signaling pathways including Hedgehog, Wnt, FGF, and PDGF. Ciliary dysfunction contributes to a range of disorders, collectively known as the ciliopathies. Recently, interest has grown in these syndromes, particularly among craniofacial biologists, as many known and putative ciliopathies have severe craniofacial defects. Herein we discuss the current understanding of ciliary biology and craniofacial development in an attempt to gain insight into the molecular etiology for craniofacial ciliopathies, and uncover a characteristic ciliopathic craniofacial gestalt.

Indexed as

PhenotypeCiliaCraniofacial AbnormalitiesEctodermFibroblast Growth FactorsHedgehog ProteinsHumansMaxillofacial DevelopmentNeural CrestNeural PlatePlatelet-Derived Growth FactorSignal TransductionSkullWnt ProteinsFibroblast Growth FactorsHedgehog ProteinsPlatelet-Derived Growth FactorWnt Proteins

Identifiers

PMID21305689
PMCPMC3118297
OpenAlexW2011919018

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.