ArticlePloS one2011
An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.Nature genetics · 2015Pooled it
- Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease.Molecular biology reports · 2014Pooled it
- Inflammatory bowel disease: a narrative review of disease evolution in South Asia and India over the last decade.Therapeutic advances in gastroenterology · 2024Review
- Global burden of inflammatory bowel disease 1990-2019: A systematic examination of the disease burden and twenty-year forecast.World journal of gastroenterology · 2023Article
- Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes.BMC genomics · 2023Article
- Colitis and Crohn's Foundation (India): a first nationwide inflammatory bowel disease registry.Intestinal research · 2021Article
- Inflammatory bowel disease: An Indian perspective.The Indian journal of medical research · 2021Review
- Inflammatory bowel disease in India: challenges and opportunities.Frontline gastroenterology · 2021Article
- The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.International journal of molecular sciences · 2020Review
- BTNL2-Ig Protein Attenuates Type 1 Diabetes in Non-Obese Diabetic (NOD) Mice.Advanced healthcare materials · 2019Article
- In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice.Cellular immunology · 2019Article
- Genetic associations of inflammatory bowel disease in a South Asian population.World journal of clinical cases · 2018Article
- Genetics of ulcerative colitis: putting into perspective the incremental gains from Indian studies.Journal of genetics · 2018Review
- The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease.BMC research notes · 2018Article
- Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East.Inflammatory intestinal diseases · 2017Review
- Inflammatory bowel disease in India - Past, present and future.World journal of gastroenterology · 2016Review
- Article
- Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians.Genes and immunity · 2016Article
- Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases.Journal of pediatric gastroenterology and nutrition · 2016Review
- Association of genetic polymorphisms on BTNL2 with susceptibility to and prognosis of dilated cardiomyopathy in a Chinese population.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-Wide Association studies (GWAS) of both Crohn's Disease (CD) and Ulcerative Colitis (UC) have unearthed over 40 risk conferring variants. Recently, a meta-analysis on UC revealed several loci, most of which were either previously associated with UC or CD susceptibility in populations of European origin. In this study, we attempted to replicate these findings in an ethnically distinct north Indian UC cohort. 648 UC cases and 850 controls were genotyped using Infinium Human 660W-quad. Out of 59 meta-analysis index SNPs, six were not in the SNP array used in the study. Of the remaining 53 SNPs, four were found monomorphic. Association (p<0.05) at 25 SNPs was observed, of which 15 were CD specific. Only five SNPs namely rs2395185 (HLA-DRA), rs3024505 (IL10), rs6426833 (RNF186), rs3763313 (BTNL2) and rs2066843 (NOD2) retained significance after Bonferroni correction. These results (i) reveal limited replication of Caucasian based meta-analysis results; (ii) reiterate overlapping molecular mechanism(s) in UC and CD; (iii) indicate differences in genetic architecture between populations; and (iv) suggest that resources such as HapMap need to be extended to cover diverse ethnic populations. They also suggest a systematic GWAS in this terrain may be insightful for identifying population specific IBD risk conferring loci and thus enable cross-ethnicity fine mapping of disease loci.
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