ArticlePloS one2011
The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic interaction for emotional and behavioral symptoms of alcohol withdrawal syndrome.BMC psychiatry · 2024Article
- Roles and mechanisms of ankyrin-G in neuropsychiatric disorders.Experimental & molecular medicine · 2022Review
- ANK3 Gene Polymorphism Rs10994336 Influences Executive Functions by Modulating Methylation in Patients With Bipolar Disorder.Frontiers in neuroscience · 2021Article
- Review of animal models of bipolar disorder that alter ion regulation.Neuroscience and biobehavioral reviews · 2019Review
- Article
- Telomere Length and Bipolar Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Towards person-centered neuroimaging markers for resilience and vulnerability in Bipolar Disorder.NeuroImage · 2017Article
- Multimodal Neuroimaging-Informed Clinical Applications in Neuropsychiatric Disorders.Frontiers in psychiatry · 2016Article
- New developments in the genetics of bipolar disorder.Current psychiatry reports · 2014Review
- Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders.The international journal of neuropsychopharmacology · 2014Article
- Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis.Journal of psychiatry & neuroscience : JPN · 2014Article
- Lithium's role in neural plasticity and its implications for mood disorders.Acta psychiatrica Scandinavica · 2013Review
- Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.Molecular psychiatry · 2013Article
- Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology.Biology of mood & anxiety disorders · 2012Article
- Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.Psychiatric genetics · 2012Article
- Dissociable and common deficits in inhibitory control in schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2012Article
- Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder.Pharmacology, biochemistry, and behavior · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities in cognition have been reported in patients with Bipolar Disorder (BD) and their first degree relatives, suggesting that susceptibility genes for BD may impact on cognitive processes. Recent genome-wide genetic studies have reported a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of sodium gated ion channels. Since ANK3 influences the efficiency of transmission of neuronal impulses, allelic variation in this gene may have widespread cognitive effects. Preclinical data suggest that this may principally apply to sequential signal detection, a core process of sustained attention. METHODOLOGY/PRINCIPAL
findingsOne hundred and eighty-nine individuals of white British descent were genotyped for the ANK3 rs10994336 polymorphism and received diagnostic interviews and comprehensive neurocognitive assessment of their general intellectual ability, memory, decision making, response inhibition and sustained attention. Participants comprised euthymic BD patients (n = 47), their unaffected first-degree relatives (n = 75) and healthy controls (n = 67). The risk allele T was associated with reduced sensitivity in target detection (p = 0.0004) and increased errors of commission (p = 0.0018) during sustained attention regardless of diagnosis. We found no effect of the ANK3 genotype on general intellectual ability, memory, decision making and response inhibition. CONCLUSIONS/SIGNIFICANCE: Our results suggest that allelic variation in ANK3 impacts cognitive processes associated with signal detection and this mechanism may relate to risk for BD. However, our results require independent replication and confirmation that ANK3 (rs10994336) is a direct functional variant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.