ArticlePloS one2011
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease.Journal of internal medicine · 2026Review
- Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders.Inflammation · 2024Review
- Intravesical Bacille Calmette-Guerin (BCG) Vaccine Affects Cognition.Journal of Alzheimer's disease : JAD · 2024Article
- Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies.PloS one · 2023Observational
- Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.Journal of neuroinflammation · 2022Article
- Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice.Human vaccines & immunotherapeutics · 2022Article
- BCG Vaccine-The Road Not Taken.Microorganisms · 2022Review
- Secondary Prevention in Radiologically Isolated Syndromes and Prodromal Stages of Multiple Sclerosis.Frontiers in neurology · 2022Review
- TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines.Human vaccines & immunotherapeutics · 2021Article
- Article
- Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat.Frontiers in cellular and infection microbiology · 2019Review
- Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.Frontiers in immunology · 2018Review
- α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.Journal of neuroinflammation · 2016Article
- Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons.Human vaccines & immunotherapeutics · 2016Article
- Brain-gut-microbiota axis in Parkinson's disease.World journal of gastroenterology · 2015Review
- Insights into Neuroinflammation in Parkinson's Disease: From Biomarkers to Anti-Inflammatory Based Therapies.BioMed research international · 2015Review
- Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Human vaccines & immunotherapeutics · 2014Review
- TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.Frontiers in immunology · 2013Article
- Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Journal of neuroscience research · 2013Article
- Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
There is a growing interest in using vaccination with CNS antigens to induce autoreactive T cell responses that home to damaged areas in the CNS and ameliorate neurodegenerative disease. Neuroprotective vaccine studies have focused on administering oligodendrocyte antigens or Copaxone® in complete Freund's adjuvant (CFA). Theoretical considerations, however, suggest that vaccination with a neuronal antigen may induce more robust neuroprotective immune responses. We assessed the neuroprotective potential of vaccines containing tyrosine hydroxylase (a neuronal protein involved in dopamine synthesis) or Copaxone® in CFA in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Surprisingly, we observed that the main beneficial factor in these vaccines was the CFA. Since the major immunogenic component in CFA is Mycobacterium tuberculosis, which closely related to the bacille Calmette-Guérin (BCG) that is used in human vaccines, we tested BCG vaccination in the MPTP mouse model. We observed that BCG vaccination partially preserved markers of striatal dopamine system integrity and prevented an increase in activated microglia in the substantia nigra of MPTP-treated mice. These results support a new neuroprotective vaccine paradigm in which general (nonself-reactive) immune stimulation in the periphery can limit potentially deleterious microglial responses to a neuronal insult and exert a neurorestorative effect in the CNS. Accordingly, BCG vaccination may provide a new strategy to augment current treatments for a wide range of neuropathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.