ArticlePloS one2011
Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 123 citations in OpenAlex.
- Trial
- Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Activation of the AMPK Signaling and Brain Function: A Friend or Foe?Journal of neurochemistry · 2025Review
- Dietary Factors and Cognitive Function: with a Focus on Subjective Cognitive Decline.Current nutrition reports · 2025Review
- SIRT1, resveratrol and aging.Frontiers in genetics · 2024Review
- Blood-to-brain communication in aging and rejuvenation.Nature neuroscience · 2023Review
- The gut microbiota is an emerging target for improving brain health during ageing.Gut microbiome (Cambridge, England) · 2023Article
- Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes.Neurobiology of aging · 2022Article
- Overweight Management through Mild Caloric Restriction in Multigenerational Long-Tailed Macaque Breeding Groups.Veterinary sciences · 2022Article
- Long-term intake of total energy and fat in relation to subjective cognitive decline.European journal of epidemiology · 2022Article
- Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- Does calorie restriction improve cognition?IBRO reports · 2020Article
- Neurobiological substrates of animal personality and cognition in a nonhuman primate (Microcebus murinus).Brain and behavior · 2020Article
- Resveratrol Modulates and Reverses the Age-Related Effect on Adenosine-Mediated Signalling in SAMP8 Mice.Molecular neurobiology · 2019Article
- Strengths and Weaknesses of the Gray Mouse Lemur (Frontiers in pharmacology · 2019Review
- Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.Aging and disease · 2018Review
- Infant titi monkey behavior in the open field test and the effect of early adversity.American journal of primatology · 2017Article
- The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite.PLoS biology · 2017Article
- Translational models for vascular cognitive impairment: a review including larger species.BMC medicine · 2017Review
- Polyphenols Beyond Barriers: A Glimpse into the Brain.Current neuropharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of an 18-month treatment with a moderate, chronic caloric restriction (CR) or an oral supplementation with resveratrol (RSV), a potential CR mimetic, on cognitive and motor performances were studied in non-human primates, grey mouse lemurs (Microcebus murinus).Thirty-three adult male mouse lemurs were assigned to three different groups: a control (CTL) group fed ad libitum, a CR group fed 70% of the CTL caloric intake, and an RSV group (RSV supplementation of 200 mg.kg(-1).day(-1)) fed ad libitum. Three different cognitive tests, two motor tests, one emotional test and an analysis of cortisol level were performed in each group.Compared to CTL animals, CR or RSV animals did not show any change in motor performances evaluated by rotarod and jump tests, but an increase in spontaneous locomotor activity was observed in both groups. Working memory was improved by both treatments in the spontaneous alternation task. Despite a trend for CR group, only RSV supplementation increased spatial memory performances in the circular platform task. Finally, none of these treatments induced additional stress to the animals as reflected by similar results in the open field test and cortisol analyses compared to CTL animals.The present data provided the earliest evidence for a beneficial effect of CR or RSV supplementation on specific cognitive functions in a primate. Taken together, these results suggest that RSV could be a good candidate to mimic long-term CR effects and support the growing evidences that nutritional interventions can have beneficial effects on brain functions even in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.