ArticlePLoS computational biology2011
Stochastic theory of early viral infection: continuous versus burst production of virions.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- A hybrid framework for compartmental models enabling simulation-based inference.Journal of mathematical biology · 2026Article
- Dissecting the steps in early simian immunodeficiency virus dissemination following mucosal and intravenous infection of rhesus macaques.Journal of virology · 2026Article
- Stochastic modelling of viral infection spread via a Partial Integro-Differential Equation.Infectious Disease Modelling · 2025Article
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.PLoS biology · 2025Article
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.bioRxiv : the preprint server for biology · 2025Article
- The kinetics of SARS-CoV-2 infection based on a human challenge study.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Probability of early infection extinction depends linearly on the virus clearance rate.Royal Society open science · 2024Article
- Decay of HCoV-OC43 infectivity is lower in cell debris-containing media than in fresh culture media.microPublication biology · 2024Article
- The reproduction number and its probability distribution for stochastic viral dynamics.Journal of the Royal Society, Interface · 2024Article
- The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy.Scientific reports · 2023Article
- Patch formation driven by stochastic effects of interaction between viruses and defective interfering particles.PLoS computational biology · 2023Article
- Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection.Journal of theoretical biology · 2023Article
- A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques.Mathematical biosciences · 2023Article
- Article
- A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response.Journal of theoretical biology · 2022Article
- Viro-fluidics: Real-time analysis of virus production kinetics at the single-cell level.Biophysical reports · 2022Article
- Article
- Viral Aggregation: The Knowns and Unknowns.Viruses · 2022Review
- Sensitivity of SARS-CoV-2 Life Cycle to IFN Effects and ACE2 Binding Unveiled with a Stochastic Model.Viruses · 2022Article
13 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Viral production from infected cells can occur continuously or in a burst that generally kills the cell. For HIV infection, both modes of production have been suggested. Standard viral dynamic models formulated as sets of ordinary differential equations can not distinguish between these two modes of viral production, as the predicted dynamics is identical as long as infected cells produce the same total number of virions over their lifespan. Here we show that in stochastic models of viral infection the two modes of viral production yield different early term dynamics. Further, we analytically determine the probability that infections initiated with any number of virions and infected cells reach extinction, the state when both the population of virions and infected cells vanish, and show this too has different solutions for continuous and burst production. We also compute the distributions of times to establish infection as well as the distribution of times to extinction starting from both a single virion as well as from a single infected cell for both modes of virion production.
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