ArticlePloS one2011
Study of muscle cell dedifferentiation after skeletal muscle injury of mice with a Cre-Lox system.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture.The Journal of general physiology · 2026Article
- Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolongedbioRxiv : the preprint server for biology · 2025Article
- Article
- Non-viral, Tumor-free Induction of Transient Cell Reprogramming in Mouse Skeletal Muscle to Enhance Tissue Regeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.Journal of tissue engineering and regenerative medicine · 2018Article
- Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications.Scientific reports · 2017Article
- Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals.International journal of cell biology · 2017Review
- Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation.Developmental biology · 2016Article
- Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells.Scientific reports · 2015Article
- Systems biology approach to developing S(2)RM-based "systems therapeutics" and naturally induced pluripotent stem cells.World journal of stem cells · 2015Review
- Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice.Scientific reports · 2015Article
- Article
- Possible local stem cells activation by microcurrent application in experimentally injured soleus muscle.International journal of stem cells · 2014Article
- Characterization of discrete subpopulations of progenitor cells in traumatic human extremity wounds.PloS one · 2014Article
- Twist reverses muscle cell differentiation through transcriptional down-regulation of myogenin.Bioscience reports · 2013Article
- Satellite cells and the muscle stem cell niche.Physiological reviews · 2013Review
- Article
- Slow-adhering stem cells derived from injured skeletal muscle have improved regenerative capacity.The American journal of pathology · 2011Article
- Selecting the optimal cell for kidney regeneration: fetal, adult or reprogrammed stem cells.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDedifferentiation of muscle cells in the tissue of mammals has yet to be observed. One of the challenges facing the study of skeletal muscle cell dedifferentiation is the availability of a reliable model that can confidentially distinguish differentiated cell populations of myotubes and non-fused mononuclear cells, including stem cells that can coexist within the population of cells being studied. METHODOLOGY/PRINCIPAL
findingsIn the current study, we created a Cre/Lox-β-galactosidase system, which can specifically tag differentiated multinuclear myotubes and myotube-generated mononuclear cells based on the activation of the marker gene, β-galactosidase. By using this system in an adult mouse model, we found that β-galactosidase positive mononuclear cells were generated from β-galactosidase positive multinuclear myofibers upon muscle injury. We also demonstrated that these mononuclear cells can develop into a variety of different muscle cell lineages, i.e., myoblasts, satellite cells, and muscle derived stem cells. CONCLUSIONS/SIGNIFICANCE: These novel findings demonstrated, for the first time, that cellular dedifferentiation of skeletal muscle cells actually occurs in mammalian skeletal muscle following traumatic injury in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.