ArticlePLoS genetics2011
Targeted sister chromatid cohesion by Sir2.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus.PloS one · 2026Article
- Meiotic cohesion requires Sirt1 and preserving its activity in aging oocytes reduces missegregation.EMBO reports · 2025Article
- Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion.Nature communications · 2019Article
- Distinct cellular responses to replication stress leading to apoptosis or senescence.FEBS open bio · 2019Article
- Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging ofGenetics · 2019Article
- Binding, sliding, and function of cohesin during transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Epigenetic Pathways to Ribosomal DNA Silencing.Microbiology and molecular biology reviews : MMBR · 2016Review
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Determinants of Sir2-Mediated, Silent Chromatin Cohesion.Molecular and cellular biology · 2016Article
- Linking replication stress with heterochromatin formation.Chromosoma · 2016Review
- A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere.PLoS genetics · 2016Article
- Article
- The molecular topography of silenced chromatin in Saccharomyces cerevisiae.Genes & development · 2014Article
- The spatial segregation of pericentric cohesin and condensin in the mitotic spindle.Molecular biology of the cell · 2013Article
- Epigenetics in Saccharomyces cerevisiae.Cold Spring Harbor perspectives in biology · 2013Review
- Genome-wide analysis of functional sirtuin chromatin targets in yeast.Genome biology · 2013Article
- Cohesin codes - interpreting chromatin architecture and the many facets of cohesin function.Journal of cell science · 2013Review
- The ancient and evolving roles of cohesin in gene expression and DNA repair.Current biology : CB · 2012Review
- In vitro assembly of physiological cohesin/DNA complexes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent chromatin, a repressive chromatin structure that functionally resembles heterochromatin of higher eukaryotes. We developed a protein-targeting assay to investigate the mechanistic basis for cohesion of silent chromatin domains. Individual silencing factors were tethered to sites where pairing of sister chromatids could be evaluated by fluorescence microscopy. We report that the evolutionarily conserved Sir2 histone deacetylase, an essential silent chromatin component, was both necessary and sufficient for cohesion. The cohesin genes were required, but the Sir2 deacetylase activity and other silencing factors were not. Binding of cohesin to silent chromatin was achieved with a small carboxyl terminal fragment of Sir2. Taken together, these data define a unique role for Sir2 in cohesion of silent chromatin that is distinct from the enzyme's role as a histone deacetylase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.