ArticlePloS one2011
HCV subtype characterization among injection drug users: implication for a crucial role of Zhenjiang in HCV transmission in China.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Coblopasvir and sofosbuvir for treatment of chronic hepatitis C virus infection in China: A single-arm, open-label, phase 3 trial.Liver international : official journal of the International Association for the Study of the Liver · 2020Trial
- Growth history of hepatitis C virus among HIV/HCV co-infected patients in Guizhou Province.Frontiers in genetics · 2023Article
- Distribution pattern, molecular transmission networks, and phylodynamic of hepatitis C virus in China.PloS one · 2023Article
- Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China.BMC infectious diseases · 2021Article
- The distribution of hepatitis C virus infection in Shanghai, China: a time-spatial study.BMC infectious diseases · 2021Article
- Identification of a New HCV Subtype 6xg Among Injection Drug Users in Kachin, Myanmar.Frontiers in microbiology · 2019Article
- Induction of Huh‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway.Molecular medicine reports · 2018Article
- Hepatitis C Genotypes in Libya: Correlation with Patients' Characteristics, Level of Viremia, and Degree of Liver Fibrosis.Oman medical journal · 2017Article
- Assessment of HCV genotypes in Yunnan Province of Southwest China.Virus genes · 2017Article
- Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution.Virology journal · 2017Review
- Molecular epidemiology of hepatitis C infections in Ningxia, China: genotype, phylogeny and mutation analysis.Virology journal · 2016Article
- Article
- Phylogenetic analysis of HCV subgenotypes in patients from Sichuan province in China based on the NS5B region.International journal of molecular medicine · 2015Article
- Article
- Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection.Journal of gastroenterology and hepatology · 2014Article
- The current hepatitis C virus prevalence in China may have resulted mainly from an officially encouraged plasma campaign in the 1990s: a coalescence inference with genetic sequences.Journal of virology · 2013Article
- Hepatitis C virus genotype diversity among intravenous drug users in Yunnan Province, Southwestern China.PloS one · 2013Article
- Article
- Different HCV genotype distributions of HIV-infected individuals in Henan and Guangxi, China.PloS one · 2012Article
- High Prevalence of Hepatitis C virus Among Injection Drug Users in Zhenjiang, Jiangsu, China.Indian journal of virology : an official organ of Indian Virological Society · 2011Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHCV transmission is closely associated with drug-trafficking routes in China. However, the transmission route of HCV in Eastern China remains unclear. Here, we investigate the role of Zhenjiang city of Jiangsu province, an important transportation hub linking Shanghai with other regions of China, in HCV transmission. METHODOLOGY/PRINCIPAL
findingsA total of 141 whole blood samples were collected from injection drug users (IDUs) in Zhenjiang and then tested for HCV infection. Of them, 115 HCV positive plasmas were subjected to RNA extraction, RT-PCR amplification, and sequencing. The subtype characterization and the evolutionary origin of HCV strains circulating in Zhenjiang were determined using polygenetic or phylogeographic analyses. Seven HCV subtypes 1b, 2a, 3a, 3b, 6a, 6e and 6n were detected among Zhenjiang IDUs, showing a complex HCV epidemic. The most predominant subtypes were 3a (38%) and 1b (26.8%). Among these subtypes, subtypes 3b, 6n and 6e originated from Southwestern China (i.e., Yunnan and/or Guangxi), subtypes 2a and 6a from Southern China (i.e., Guangdong), subtype 1b from Central (i.e., Henan) and Northwestern (i.e., Xinjiang) China, and subtype 3a from Southwestern (i.e., Yunnan) and Northwestern (i.e., Xinjiang) China. From Zhenjiang, subtypes 1b and 2a were further spread to Eastern (i.e., Shanghai) and Northern (i.e., Beijing) China, respectively. CONCLUSIONS/SIGNIFICANCE: The mixing of seven HCV subtypes in Zhenjiang from all quarters of China indicates that as an important middle station, Zhenjiang plays a crucial role in HCV transmission, just as it is important in population migration between other regions of China and Eastern China.
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