Evidence map›Paper›PMID 21304558›Full record

ArticleEuropean journal of human genetics : EJHG2011

Identification of regions of positive selection using Shared Genomic Segment analysis.

Zheng Cai, Nicola J Camp, Lisa Cannon-Albright, Alun Thomas

Open access · bronzeAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zheng CaiDepartment of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. z.cai@utah.edu
Nicola J Camp
Lisa Cannon-Albright
Alun Thomas
University of Utah · USGeorge E. Wahlen Department of VA Medical Center · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
GENETIC EPIDEMIOLOGY OF CHRONIC LYMPHOCYTIC LEUKEMIAR01CA134674 · NCI · UNIVERSITY OF UTAH · PI CAMP, NICOLA J. · 2010 to 2016
$3.8M
Graphical models for linkage disequilibrium in genetic mappingR01GM081417 · NIGMS · UNIVERSITY OF UTAH · PI THOMAS, ALUN · 2007 to 2010
$1.1M
NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA134674NCI NIH HHS R01CA134674NIGMS NIH HHS R01 GM081417NIGMS NIH HHS R01 GM81417
6 · The paper itself

Abstract

We applied a shared genomic segment (SGS) analysis, incorporating an error model, to identify complete, or near complete, selective sweeps in the HapMap phase II data sets. This method is based on detecting heterozygous sharing across all individuals within a population, to identify regions of sharing with at least one allele in common. We identified multiple interesting regions, many of which are concordant with positive selection regions detected by previous population genetic tests. Others are suggested to be novel regions. Our finding illustrates the utility of SGS as a method for identifying regions of selection, and some of these regions have been proposed to be candidate regions for harboring disease genes.

Indexed as

Genetic VariationSelection, GeneticAlgorithmsDatabases, GeneticGene FrequencyGenetics, PopulationGenome, HumanGenomicsHaplotypesHeterozygoteHumansModels, GeneticPopulation GroupsSample SizeSoftware

Identifiers

PMID21304558
PMCPMC3110045
OpenAlexW2007451334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.