ArticleHeredity2011
Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.
Article in Heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Elephants as an animal model for self-domestication.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genes Positively Selected in Domesticated Mammals Are Significantly Dysregulated in the Blood of Individuals with Autism Spectrum Disorders.Molecular syndromology · 2020Article
- Rapid behavioral assay using handling test provides breed and sex differences in tameness of chickens.Brain and behavior · 2019Article
- Nature versus nurture? Consequences of short captivity in early stages.Ecology and evolution · 2018Article
- Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes).PloS one · 2015Article
- Genetic influences on brain gene expression in rats selected for tameness and aggression.Genetics · 2014Article
- The "domestication syndrome" in mammals: a unified explanation based on neural crest cell behavior and genetics.Genetics · 2014Article
- Whole-genome sequencing of Berkshire (European native pig) provides insights into its origin and domestication.Scientific reports · 2014Article
- Selection for reluctance to avoid humans during the domestication of mice.Genes, brain, and behavior · 2013Article
- Targeted enrichment of the black cottonwood (Populus trichocarpa) gene space using sequence capture.BMC genomics · 2012Article
- Demographic inference using spectral methods on SNP data, with an analysis of the human out-of-Africa expansion.Genetics · 2012Article
- A comparison of brain gene expression levels in domesticated and wild animals.PLoS genetics · 2012Article
- Article
- Deciphering the genetic basis of animal domestication.Proceedings. Biological sciences · 2011Review
Corrections and comments
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Authors and funding
18 authors at 11 institutions in 5 countries.
Funding
Abstract
The identification of the causative genetic variants in quantitative trait loci (QTL) influencing phenotypic traits is challenging, especially in crosses between outbred strains. We have previously identified several QTL influencing tameness and aggression in a cross between two lines of wild-derived, outbred rats (Rattus norvegicus) selected for their behavior towards humans. Here, we use targeted sequence capture and massively parallel sequencing of all genes in the strongest QTL in the founder animals of the cross. We identify many novel sequence variants, several of which are potentially functionally relevant. The QTL contains several regions where either the tame or the aggressive founders contain no sequence variation, and two regions where alternative haplotypes are fixed between the founders. A re-analysis of the QTL signal showed that the causative site is likely to be fixed among the tame founder animals, but that several causative alleles may segregate among the aggressive founder animals. Using a formal test for the detection of positive selection, we find 10 putative positively selected regions, some of which are close to genes known to influence behavior. Together, these results show that the QTL is probably not caused by a single selected site, but may instead represent the joint effects of several sites that were targets of polygenic selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.