ArticlemBio2011
Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh.
Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed, 149 citations in OpenAlex.
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- Structural basis of multimodal adsorption and infection initiation bybioRxiv : the preprint server for biology · 2026Article
- ICP1 bacteriophage treatment antagonizes colonization of the zebrafish larval intestine byMicrobiology spectrum · 2026Article
- Modular small RNA drives the emergence of virulence traits and environmental trade-offs in Vibrio cholerae.Nature communications · 2026Article
- Molecular Methods to DetectmedRxiv : the preprint server for health sciences · 2026Article
- Bacterial-viral conflicts shape cholera evolution.Nature · 2026Article
- Repurposing anti-phage defenses to differentially arrest the viral lifecycle reveals the regulatory logic of a parasitic satellite.bioRxiv : the preprint server for biology · 2026Article
- A colorimetric method for detecting virulent bacteriophage to Vibrio cholerae in fecal and environmental samples.PLoS neglected tropical diseases · 2025Article
- Natural products influence bacteriophage infectivity.Natural product reports · 2025Review
- Phages use contingency loci as a bet-hedging strategy.bioRxiv : the preprint server for biology · 2025Article
- Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- A DNA nicking Class 1 OLD family nuclease mediates phage defense in Vibrio cholerae and is countered by a phage-encoded inhibitor.Nucleic acids research · 2025Article
- West African-South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems.Nature microbiology · 2025Article
- Cholera rapid diagnostic tests at the host-microbe interface: Key Considerations for Global Deployments.medRxiv : the preprint server for health sciences · 2025Article
- Assembly and performance of a cholera RDT prototype that detects bothJournal of clinical microbiology · 2025Article
- Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation.Nature microbiology · 2025Article
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- AJournal of bacteriology · 2024Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Lytic bacteriophages are hypothesized to contribute to the seasonality and duration of cholera epidemics in Bangladesh. However, the bacteriophages contributing to this phenomenon have yet to be characterized at a molecular genetic level. In this study, we isolated and sequenced the genomes of 15 bacteriophages from stool samples from cholera patients spanning a 10-year surveillance period in Dhaka, Bangladesh. Our results indicate that a single novel bacteriophage type, designated ICP1 (for the International Centre for Diarrhoeal Disease Research, Bangladesh cholera phage 1) is present in all stool samples from cholera patients, while two other bacteriophage types, one novel (ICP2) and one T7-like (ICP3), are transient. ICP1 is a member of the Myoviridae family and has a 126-kilobase genome comprising 230 open reading frames. Comparative sequence analysis of ICP1 and related isolates from this time period indicates a high level of genetic conservation. The ubiquitous presence of ICP1 in cholera patients and the finding that the O1 antigen of lipopolysaccharide (LPS) serves as the ICP1 receptor suggest that ICP1 is extremely well adapted to predation of human-pathogenic V. cholerae O1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.