ReviewThe Journal of neuropsychiatry and clinical neurosciences2011
A review of the brain structure correlates of successful cognitive aging.
Review in The Journal of neuropsychiatry and clinical neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review.Neuropsychology review · 2016Pooled it
- Trial
- Multimodal MRI prediction of cognitive functioning across the lifespan: separating between-person differences from within-person changes.GeroScience · 2026Article
- Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change.Nature communications · 2025Article
- Decoding cognitive aging: how white matter tracts and demographics distinguish potential Super-Agers.GeroScience · 2025Article
- Cross-Sectional Associations of Peripheral Hearing, Brain Imaging, and Cognitive Performance With Speech-in-Noise Performance: The Aging and Cognitive Health Evaluation in Elders Brain Magnetic Resonance Imaging Ancillary Study.American journal of audiology · 2024Article
- Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.Neurobiology of aging · 2024Article
- Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression.Human genomics · 2024Article
- The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis.Brain imaging and behavior · 2024Article
- Age-related enhancement of the association between episodic memory and gray matter volume in medial temporal and frontal lobes.Behavioral and brain functions : BBF · 2024Article
- Differential predictability of cognitive profiles from brain structure in older males and females.GeroScience · 2024Article
- Sex-Specific Association of Body Mass Index with Hippocampal Subfield Volume and Cognitive Function in Non-Demented Chinese Older Adults.Brain sciences · 2024Article
- Anti-saccade as a tool to evaluate cognitive impairment in vestibular migraine.Frontiers in neurology · 2024Article
- Eight brain structures mediate the age-related alterations of the working memory: forward and backward digit span tasks.Frontiers in psychology · 2024Article
- Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment.Advanced biology · 2023Review
- C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank.Brain, behavior, & immunity - health · 2023Article
- Anticholinergic burden in middle and older age is associated with lower cognitive function, but not with brain atrophy.British journal of clinical pharmacology · 2023Article
- Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer's Disease in Democratic Republic of Congo.Journal of Alzheimer's disease : JAD · 2023Article
- Memory, aging and the brain: Old findings and current issues.Aging brain · 2023Article
- Interpretable deep learning of myelin histopathology in age-related cognitive impairment.Acta neuropathologica communications · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Unimpaired cognition is an important feature of successful aging. Differences in cognitive performance among healthy older adults may be related to differences in brain structure. The authors reviewed the literature to examine the relationship between brain-structure size and cognitive performance in older adults. Eighty-three percent of studies found at least one positive relationship between these factors; however, findings were variable. Positive relationships emerged most consistently between the hippocampal formation and global cognition and memory and between frontal measures and executive function. Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.