ArticleJournal of diabetes science and technology2011
The design and development of fluorescent nano-optodes for in vivo glucose monitoring.
Article in Journal of diabetes science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A fluorous-phase oxygen optical nanosensor for mitigating redox-active microbial metabolite interference.The Analyst · 2026Article
- Recent Progress in Nanobiosensors for Precise Detection of Blood Glucose Level.Biochemistry research international · 2022Review
- Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment.Trends in endocrinology and metabolism: TEM · 2020Review
- Real-time particle-by-particle detection of erythrocyte-camouflaged microsensor with extended circulation time in the bloodstream.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes.Journal of diabetes research · 2016Article
- Glucose-sensitive nanofiber scaffolds with an improved sensing design for physiological conditions.The Analyst · 2015Article
- Managing diabetes with nanomedicine: challenges and opportunities.Nature reviews. Drug discovery · 2015Review
- Implantable nanosensors: toward continuous physiologic monitoring.Analytical chemistry · 2014Review
- Gel encapsulation of glucose nanosensors for prolonged in vivo lifetime.Journal of diabetes science and technology · 2013Article
- Overview of fluorescence glucose sensing: a technology with a bright future.Journal of diabetes science and technology · 2012Review
- Biodegradable optode-based nanosensors for in vivo monitoring.Analytical chemistry · 2012Article
- Improved outcomes from diabetes monitoring: the benefits of better adherence, therapy adjustments, patient education, and telemedicine support.Journal of diabetes science and technology · 2012Article
- Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and the foreign body response-part I: theoretical framework.Journal of diabetes science and technology · 2011Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe advent of fluorescent nanosensors has enabled intracellular monitoring of several physiological analytes, which was previously not possible with molecular dyes or other invasive techniques. We have extended the capability of these sensors to include the detection of small molecules with the development of glucose-sensitive nano-optodes. Herein, we discuss the design and development of glucose-sensitive nano-optodes, which have been proven functional both in vitro and in vivo.
methodsThroughout the design process, each of the sensor formulations was evaluated based on their response to changes in glucose levels. The percent change in signal, sensor reversibility, and the overall fluorescence intensity were the specific parameters used to assess each formulation.
resultsA hydrophobic boronic acid was selected that yielded a fully reversible fluorescence response to glucose in accordance with the sensor mechanism. The change in fluorescence signal in response to glucose was approximately 11%. The use of different additives or chromophores did not improve the response; however, modifications to the plasticized polymeric membrane extended sensor lifetime.
conclusionsSensors were developed that yielded a dynamic response to glucose and through further modification of the components, sensor lifetime was improved. By following specific design criteria for the macrosensors, the sensors were miniaturized into nano-optodes that track changes in glucose levels in vivo.
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Registered trials
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