ArticleMolecular imaging2011
Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles.
Article in Molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics.ChemMedChem · 2022Review
- Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease.Physiological reports · 2020Article
- Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis.Frontiers in bioengineering and biotechnology · 2020Review
- Trends towards Biomimicry in Theranostics.Nanomaterials (Basel, Switzerland) · 2018Review
- Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles.Frontiers in pharmacology · 2018Review
- Nanometer size silicon particles for hyperpolarized MRI.Scientific reports · 2017Article
- Uterus-targeted liposomes for preterm labor management: studies in pregnant mice.Scientific reports · 2016Article
- Multistage Delivery Technologies: Multifunctional, Interdisciplinary Approaches to Nanomedicine.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases.Cancer research · 2016Article
- Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues.Nature communications · 2015Article
- Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs.Current drug targets · 2015Article
- The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation.Biomaterials · 2014Article
- In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice.Pharmaceutical research · 2014Article
- Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential.Journal of materials chemistry. B · 2013Article
- Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers.Cancer letters · 2013Article
- Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Silicon micro- and nanofabrication for medicine.Advanced healthcare materials · 2013Review
- In vivo magnetic resonance imaging of hyperpolarized silicon particles.Nature nanotechnology · 2013Article
- Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.ACS nano · 2013Article
- Biocompatibility assessment of Si-based nano- and micro-particles.Advanced drug delivery reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
In the development of new nanoparticle-based technologies for therapeutic and diagnostic purposes, understanding the fate of nanoparticles in the body is crucial. We recently developed a multistage vector delivery system comprising biodegradable and biocompatible nanoporous silicon particles (first-stage microparticles [S1MPs]) able to host, protect, and deliver second-stage therapeutic and diagnostic nanoparticles (S2NPs) on intravenous injection. This delivery system aims at sequentially overcoming the biologic barriers en route to the target delivery site by separating and assigning tasks to the coordinated logic-embedded vectors constituting it. In this work, by conjugating a near-infrared dye on the surface of the S1MP without compromising the porous structure and potential loading of S2NPs, we were able to monitor the in vivo distribution of S1MPs in healthy mice using an optical imaging system. It was observed that particles predominantly accumulated in the liver and spleen at the end of 24 hours. Further quantification of S1MPs in the major organs of the animals by elemental analysis of silicon using inductively coupled plasma-atomic electron spectroscopy verified the accuracy of in vivo near-infrared imaging as a tool for evaluation of nanovector biodistribution.
Indexed as
Identifiers
21303615PMC3088648What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.