ArticleClinical and molecular allergy : CMA2011
Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.
Article in Clinical and molecular allergy : CMA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Immunopharmacological potential ofFrontiers in pharmacology · 2025Review
- Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications.Natural products and bioprospecting · 2024Review
- Optimizing the Fermentation Conditions ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated fromMarine drugs · 2022Article
- Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling.BMC complementary medicine and therapies · 2021Article
- Identification of a Biostimulating Potential of an Organic Biomaterial Based on the Botanical Extract fromMaterials (Basel, Switzerland) · 2021Article
- Derma-Hc, a New Developed Herbal Formula, Ameliorates Cutaneous Lichenification in Atopic Dermatitis.International journal of molecular sciences · 2021Article
- Article
- Impact of Nutritional Supplementation on Canine Dermatological Disorders.Veterinary sciences · 2020Review
- Acceptability, tolerability, and effects on symptoms and signs of vulvovaginitis of a non-soap, herbal-based intimate hygiene solution (Zelesse®).The Journal of international medical research · 2019Observational
- Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.Acta pharmacologica Sinica · 2018Review
- Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Protective effects of Arctium lappa L. roots against hydrogen peroxide-induced cell injury and potential mechanisms in SH-SY5Y cells.Cellular and molecular neurobiology · 2015Article
- Huangzhi Oral Liquid Prevents Arrhythmias by Upregulating Caspase-3 and Apoptosis Network Proteins in Myocardial Ischemia-Reperfusion Injury in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effect of plant extracts on H2O2-induced inflammatory gene expression in macrophages.Journal of inflammation research · 2014Article
- Anti-leishmanial effect of the hydroalcoholic extract of the leaves, roots and seeds ofAvicenna journal of phytomedicineArticle
- Antidiabetic, hypolipidemic and hepatoprotective effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa L. is a traditional medicine in Asia. This study examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
methodsThis study examined the effect of ALBE on the release of β-hexosaminidase in antigen-stimulated-RBL-2H3 cells. We also evaluated the ConA-induced expression of IL-4, IL-5, mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-κB using RT-PCR, Western blotting, and ELISA in mouse splenocytes after ALBE treatment.
resultsWe observed significant inhibition of β-hexosaminidase release in RBL-2H3 cells and suppressed mRNA expression and protein secretion of IL-4 and IL-5 induced by ConA-treated primary murine splenocytes after ALBE treatment. Additionally, ALBE (100 μg/mL) suppressed not only the transcriptional activation of NF-κB, but also the phosphorylation of MAPKs in ConA-treated primary splenocytes.
conclusionsThese results suggest that ALBE inhibits the expression of IL-4 and IL-5 by downregulating MAPKs and NF-κB activation in ConA-treated splenocytes and supports the hypothesis that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.