ArticleClinical and experimental immunology2011
Smoking and periodontal disease: discrimination of antibody responses to pathogenic and commensal oral bacteria.
Article in Clinical and experimental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Comparison of oral conditions between the Macuxi and Yanomami indigenous ethnicities.Brazilian oral research · 2025Article
- Heterogeneity of human serum antibody responses to P. gingivalis in periodontitis: Effects of age, race/ethnicity, and sex.Immunology letters · 2020Article
- Inhibition of osteoclastogenesis by opsonizedFASEB bioAdvances · 2019Article
- Ageing effects on humoral immune responses in chronic periodontitis.Journal of clinical periodontology · 2018Article
- Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence.Anaerobe · 2018Review
- Cross-talk between clinical and host-response parameters of periodontitis in smokers.Journal of periodontal research · 2017Article
- Integrated biomarker profiling of smokers with periodontitis.Journal of clinical periodontology · 2017Article
- Article
- Smoking-related cotinine levels and host responses in chronic periodontitis.Journal of periodontal research · 2014Article
- Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis.Journal of periodontology · 2014Article
- Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis.Journal of clinical periodontology · 2014Article
- Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study.Cancer causes & control : CCC · 2013Article
- Quantitative estimation of sodium, potassium and total protein in saliva of diabetic smokers and nonsmokers: A novel study.Journal of natural science, biology, and medicine · 2013Article
- Periodontal disease immunology: 'double indemnity' in protecting the host.Periodontology 2000 · 2013Review
- Smoking and periodontal disease.Materia socio-medica · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is an independent risk factor for the initiation, extent and severity of periodontal disease. This study examined the ability of the host immune system to discriminate commensal oral bacteria from pathogens at mucosal surfaces, i.e. oral cavity. Serum immunoglobulin (Ig)G antibody reactive with three pathogenic and five commensal oral bacteria in 301 current smokers (age range 21-66 years) were examined by enzyme-linked immunosorbent assay. Clinical features of periodontal health were used as measures of periodontitis. Antibody to the pathogens and salivary cotinine levels were related positively to disease severity; however, the antibody levels were best described by the clinical disease unrelated to the amount of smoking. The data showed a greater immune response to pathogens than commensals that was related specifically to disease extent, and most noted in black males. Significant correlations in individual patient responses to the pathogens and commensals were lost with an increasing extent of periodontitis and serum antibody to the pathogens. Antibody to Porphyromonas gingivalis was particularly distinct with respect to the discriminatory nature of the immune responses in recognizing the pathogens. Antibody responses to selected pathogenic and commensal oral microorganisms differed among racial groups and genders. The antibody response to the pathogens was related to disease severity. The level of antibody to the pathogens, and in particular P. gingivalis, was correlated with disease severity in black and male subsets of patients. The amount of smoking did not appear to impact directly serum antibody levels to these oral bacteria.
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