Evidence map›Paper›PMID 21303220›Full record

ReviewTissue engineering. Part B, Reviews2011

Indentation versus tensile measurements of Young's modulus for soft biological tissues.

Clayton T McKee, Julie A Last, Paul Russell, Christopher J Murphy

Abstract readReview
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. 3DACS biomaterials science & engineering · 2023
    Pooled it
  2. Nanomechanical Hallmarks ofInternational journal of molecular sciences · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. TheMaterials today. Bio · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Clayton T McKeeDepartment of Surgical and Radiological Science, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA.
Julie A Last
Paul Russell
Christopher J Murphy

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI LISA M OAKES · 1999 to 2026
$18.9M
Modulation of Signal Transduction by Nano-TopographyR01EY016134 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, CHRISTOPHER JOHN, THOMASY, SARA MICHELLE · 2006 to 2023
$5.1M
Beyond Biomaterials: Engineering the Wound BedRC2AR058971 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBOTT, NICHOLAS L, MURPHY, CHRISTOPHER JOHN · 2009 to 2010
$4.0M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
Effects of Substratum Topography on Vascular EndotheliumR01HL079012 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, CHRISTOPHER JOHN · 2005 to 2009
$1.7M
Role of Biophysical Cues in the Pathogenesis of GlaucomaR01EY019475 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RUSSELL, PAUL · 2010 to 2013
$1.5M
Towards a synthetic basement membrane for the corneal epitheliumR01EY017367 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI NEALEY, PAUL F. · 2007 to 2010
$1.4M
NEI NIH HHS P30EY12576NEI NIH HHS R01 EY016134NEI NIH HHS R01 EY017367NEI NIH HHS R01 EY019475NEI NIH HHS R01 EY019970NEI NIH HHS R01EY19475NHLBI NIH HHS R01 HL079012NHLBI NIH HHS R01HL079012NIAMS NIH HHS RC2 AR058971NIAMS NIH HHS RC2AR058971PHS HHS R01E4016134
6 · The paper itself

Abstract

In this review, we compare the reported values of Young's modulus (YM) obtained from indentation and tensile deformations of soft biological tissues. When the method of deformation is ignored, YM values for any given tissue typically span several orders of magnitude. If the method of deformation is considered, then a consistent and less ambiguous result emerges. On average, YM values for soft tissues are consistently lower when obtained by indentation deformations. We discuss the implications and potential impact of this finding.

Indexed as

Models, BiologicalAnimalsComputer SimulationConnective TissueElastic ModulusHardnessHardness TestsHumansStress, MechanicalTensile Strength

Identifiers

PMID21303220
PMCPMC3099446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.