ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Nutrigenomics for Autism Spectrum Disorder: A Multidisciplinary Framework for Personalized Nutrition in Special Education.Clinical nutrition research · 2025Article
- Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L.BMC complementary medicine and therapies · 2022Article
- Selected Natural Products in Neuroprotective Strategies for Alzheimer's Disease-A Non-Systematic Review.International journal of molecular sciences · 2022Review
- Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms.Psychology in Russia : state of the art · 2022Article
- Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.Schizophrenia bulletin · 2020Article
- Review
- MAOA-VNTR genotype affects structural and functional connectivity in distributed brain networks.Human brain mapping · 2019Article
- Differential executive functioning in the topology of Spirit possession or dissociative disorders: an explorative cultural study.BMC psychiatry · 2019Article
- Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.Alcoholism, clinical and experimental research · 2019Article
- Predicting Violent Behavior: What Can Neuroscience Add?Trends in cognitive sciences · 2018Review
- MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory.Frontiers in human neuroscience · 2018Article
- Cognitive performance of juvenile monkeys after chronic fluoxetine treatment.Developmental cognitive neuroscience · 2017Article
- Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2017Article
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
- VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome.Frontiers in behavioral neuroscience · 2016Article
- Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.The International journal of neuroscience · 2014Article
- Preliminary investigation of the influence of dopamine regulating genes on social working memory.Social neuroscience · 2014Article
- Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning.European archives of psychiatry and clinical neuroscience · 2012Article
- Genetics of emotion.Trends in cognitive sciences · 2011Review
- Do boys with MAOA_LPR*2R allele present cognitive and learning impairments?Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Individual differences in cognitive function are highly heritable and most likely driven by multiple genes of small effect. Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. We hypothesized that 5HTTLPR genotype would show little association with prefrontal cognitive performance, but that COMT and MAOA would have interacting effects on cognition through their shared influence on prefrontal catecholamine availability. We assessed the individual and epistatic effects of functional polymorphisms in COMT, MAOA, and 5HTTLPR on children's prefrontal cognitive function in nearly 6,000 children from the population-based Avon Longitudinal Study of Parents and Children (ALSPAC). Neither MAOA nor 5HTTLPR polymorphisms showed significant effects on cognitive function. In boys but not girls, there was a modest but statistically significant interaction between MAOA and COMT genotypes such that increased prefrontal catecholamine availability was associated with better working memory. These results suggest that assessment of multiple genes within functionally related systems may improve our understanding of the genetic basis of cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.