Evidence map›Paper›PMID 21302177›Full record

ReviewNutrition and cancer2011

Modulation of glioma risk and progression by dietary nutrients and antiinflammatory agents.

Athanassios P Kyritsis, Melissa L Bondy, Victor A Levin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition and cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Antineoplastic Activity ofCurrent issues in molecular biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
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  13. Review
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  16. Review
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  18. Article
  19. Use of MendelianFrontiers in genetics · 2018
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Athanassios P KyritsisNeurosurgical Research Institute, University of Ioannina, Ioannina, Greece. thkyrits@uoi.gr
Melissa L Bondy
Victor A Levin
Kaiser Permanente · USThe University of Texas MD Anderson Cancer Center · USUniversity of Ioannina · GR

Funding

Genetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9M
MOLECULAR EPIDEMIOLOGY OF GLIOMASR01CA070917 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI BONDY, MELISSA L · 1996 to 2004
$3.0M
NCI NIH HHS CA 070917NCI NIH HHS CA 119215NCI NIH HHS R01 CA070917NCI NIH HHS R01 CA119215
6 · The paper itself

Abstract

Gliomas are tumors of glial origin formed in the central nervous system and exhibit profound morphological and genetic heterogeneity. The etiology of this heterogeneity involves an interaction between genetic alterations and environmental risk factors. Scientific evidence suggests that certain natural dietary components, such as phytoestrogens, flavonoids, polyunsaturated fatty acids, and vitamins, may exert a protective effect against gliomas by changing the nature of the interaction between genetics and environment. Similarly, certain antiinflammatory drugs and dietary modifications, such as methionine restriction and the adoption of low-calorie or ketogenic diets, may take advantage of glioma and normal glial cells' differential requirements for glucose, methionine, and ketone bodies and may, therefore, be effective as part of preventive or treatment strategies for gliomas. Treatment trials of glioma patients and chemoprevention trials of individuals with a known genetic predisposition to glioma using the most promising of these agents, such as the antiinflammatory drugs curcumin and gamma-linolenic acid, are needed to validate or refute these agents' putative role in gliomas.

Indexed as

Disease ProgressionFoodAnimalsAnti-Inflammatory AgentsChemopreventionClinical Trials as TopicDietFatty Acids, UnsaturatedGliomaHumansLife StyleModels, AnimalOxidative StressRisk FactorsVitaminsAnti-Inflammatory AgentsFatty Acids, UnsaturatedVitamins

Identifiers

PMID21302177
PMCPMC3047463
OpenAlexW2046591057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.