ArticleInflammation2012
Attenuation of hyperoxia-induced lung injury in rats by adrenomedullin.
Article in Inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches.Frontiers in pharmacology · 2025Review
- Fluorofenidone attenuates paraquat‑induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy.Molecular medicine reports · 2021Article
- Article
- Ligustrazine suppresses renal NMDAR1 and caspase-3 expressions in a mouse model of sepsis-associated acute kidney injury.Molecular and cellular biochemistry · 2020Article
- Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia.Respiratory research · 2019Article
- Interleukin-3 plays a vital role in hyperoxic acute lung injury in mice via mediating inflammation.BMC pulmonary medicine · 2018Article
- Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute Lung Injury in Mice.Inflammation · 2018Article
- Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury.BMC anesthesiology · 2018Article
- Acacetin attenuates mice endotoxin-induced acute lung injury via augmentation of heme oxygenase-1 activity.Inflammopharmacology · 2018Article
- Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway.PloS one · 2018Article
- Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways.Scientific reports · 2017Article
- Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice.Inflammation · 2016Article
- Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury.Respiratory research · 2015Article
- Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells.Biochemical and biophysical research communications · 2015Article
- Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats.Iranian journal of basic medical sciences · 2015Article
- Galangin dampens mice lipopolysaccharide-induced acute lung injury.Inflammation · 2014Article
- NF-κB involvement in hyperoxia-induced myocardial damage in newborn rat hearts.Histochemistry and cell biology · 2013Article
- Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.American journal of physiology. Lung cellular and molecular physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress and inflammation are involved in the pathogenesis of acute lung injury (ALI). Adrenomedullin (AM) is an endogenous peptide with anti-inflammatory and antioxidant properties. This study investigated that whether AM treatment may ameliorate hyperoxia-induced ALI in rats via inhibition of oxidative stress and inflammation. Rats were randomized to receive continuous intravenous infusion of AM or saline through a microosmotic pump, and then ALI was induced by exposing the animals in sealed cages >95% oxygen for 72 h. Exposure to hyperoxia caused lung injury as increased infiltration of inflammatory cells and disruption of lung architecture. AM administration markedly improved these changes. Additionally, AM administration significantly increased glutathione peroxidase and superoxide dismutase activities. Meanwhile, hyperoxia-induced increase of lipid hydroperoxide level was markedly reduced by AM treatment. Moreover, nuclear factor-kappa B-DNA-binding activity, and production of the inflammatory mediators interleukin-6, keratinocyte-derived chemokine, and matrix metalloproteinase 9, were significantly inhibited by AM treatment. AM ameliorates hyperoxia-induced ALI in rats by suppression of oxidative stress and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.