ArticleMolecular and cellular biochemistry2011
Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Long-Term Testosterone Administration on Insulin Sensitivity in Older Men With Low or Low-Normal Testosterone Levels.The Journal of clinical endocrinology and metabolism · 2018Trial
- Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes.Molecular nutrition & food research · 2025Article
- The Role of SHBG as a Marker in Male Patients with Metabolic-Associated Fatty Liver Disease: Insights into Metabolic and Hormonal Status.Journal of clinical medicine · 2024Article
- Age of Cafeteria Diet Onset Influences Obesity Phenotype in Mice in a Sex-Specific Manner.International journal of molecular sciences · 2024Article
- Androgen dysfunction in non-alcoholic fatty liver disease: Role of sex hormone binding globulin.Frontiers in endocrinology · 2022Review
- Sex-Steroid Signaling in Lung Diseases and Inflammation.Advances in experimental medicine and biology · 2021Article
- Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.Journal of Alzheimer's disease : JAD · 2017Review
- Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.The journal of sexual medicine · 2015Review
- Testosterone and insulin resistance in the metabolic syndrome and T2DM in men.Nature reviews. Endocrinology · 2013Article
- Excess aldosterone-induced changes in insulin signaling molecules and glucose oxidation in gastrocnemius muscle of adult male rat.Molecular and cellular biochemistry · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle, liver, and adipose tissue are major insulin responsive target organs that also express androgen receptor. Testosterone (T) plays a role in maintaining normal insulin sensitivity in men but its effects on insulin target tissues are not fully understood. Our previous study showed that orchidectomy impairs glucose oxidation through decreased insulin receptor (IR) mRNA expression in skeletal muscles, liver, and adipose tissue of male rat. Furthermore, T replacement restored IR mRNA expression in skeletal muscles and liver, but did not have any effect in adipose tissue. In the present study, orchidectomy decreased IR mRNA and protein levels in muscle, liver, and adipose tissue. Treatment with a combination of T plus estradiol (E) was necessary to restore the IR mRNA and protein to control levels in adipose tissue. T or E treatment alone had no effect on IR mRNA levels in adipose tissue. T alone also had no effect on the IR protein, whereas E alone had a stimulatory effect. In comparison, in muscle and liver, T or T plus E restored the IR mRNA and protein to control levels. In muscle and liver, E alone had no effect on IR mRNA expression but restored the IR protein. In addition, orchidectomy was seen to have a stimulatory effect on IRS-1 Serine(636/639) phosphorylation in the three tissues studied. Following T, E or combined supplementation to castrated rats, the pattern of IRS-1 serine phosphorylation was restored to normal control levels. Furthermore, orchidectomy decreased serum insulin and glucose oxidation in all three tissues, and this was restored by T and its combination with E replacement, whereas E alone had no effect. It is concluded from the present study that sex steroid deficiency induces impaired glucose oxidation in insulin responsive tissues, which is mediated through reduced IR expression, and increased IRS-1 serine phosphorylation.
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Registered trials
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