ArticleThe journal of headache and pain2011
Does visual cortex lactate increase following photic stimulation in migraine without aura patients? A functional (1)H-MRS study.
Article in The journal of headache and pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Alterations in metabolic flux in migraine and the translational relevance.The journal of headache and pain · 2022Review
- The Role of Metabolism in Migraine Pathophysiology and Susceptibility.Life (Basel, Switzerland) · 2021Review
- Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine.Scientific reports · 2021Article
- Neurochemical metabolite alterations of the occipital lobe in migraine without aura by proton magnetic resonance spectroscopy.The neuroradiology journal · 2020Article
- The metabolic face of migraine - from pathophysiology to treatment.Nature reviews. Neurology · 2019Review
- Targeted Acid-Sensing Ion Channel Therapies for Migraine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Metabolic assessment of a migraine model using relaxation-enhancedMagnetic resonance in medicine · 2018Article
- Spectral improvement by fourier thresholding of in vivo dynamic spectroscopy data.Magnetic resonance in medicine · 2016Article
- The use of magnetic resonance spectroscopy as a tool for the measurement of bi-hemispheric transcranial electric stimulation effects on primary motor cortex metabolism.Journal of visualized experiments : JoVE · 2014Article
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- The omics in migraine.The journal of headache and pain · 2013Review
- Magnetic resonance spectroscopy studies in migraine.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
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Abstract
Proton magnetic resonance spectroscopy ((1)H-MRS) has been used in a number of studies to assess noninvasively the temporal changes of lactate (Lac) in the activated human brain. Migraine neurobiology involves lack of cortical habituation to repetitive stimuli and a mitochondrial component has been put forward. Our group has recently demonstrated a reduction in the high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) in the occipital lobe of migraine without aura (MwoA) patients, at least in a subgroup, in a phosphorus MRS ((31)P-MRS) study. In previous studies, basal Lac levels or photic stimulation (PS)-induced Lac levels were found to be increased in patients with migraine with aura (MwA) and migraine patients with visual symptoms and paraesthesia, paresia and/or dysphasia, respectively. The aim of this study was to perform functional (1)H-MRS at 3 T in 20 MwoA patients and 20 control subjects. Repetitive visual stimulation was applied using MR-compatible goggles with 8 Hz checkerboard stimulation during 12 min. We did not observe any significant differences in signal integrals, ratios and absolute metabolite concentrations, including Lac, between MwoA patients and controls before PS. Lac also did not increase significantly during and following PS, both for MwoA patients and controls. Subtle Lac changes, smaller than the sensitivity threshold (i.e. estimated at 0.1-0.2 μmol/g at 3 T), cannot be detected by MRS. Our study does, however, argue against a significant switch to non-aerobic glucose metabolism during long-lasting PS of the visual cortex in MwoA patients.
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