ReviewVirchows Archiv : an international journal of pathology2011
Ductal plates in hepatic ductular reactions. Hypothesis and implications. III. Implications for liver pathology.
Review in Virchows Archiv : an international journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Key Histopathologic Features of Liver Biopsies That Distinguish Biliary Atresia From Other Causes of Infantile Cholestasis and Their Correlation With Outcome: A Multicenter Study.The American journal of surgical pathology · 2016Trial
- Clinical associations of portal-based disease in MASLD: proposal of a new histological scoring system.Virchows Archiv : an international journal of pathology · 2025Article
- Mallory-Denk bodies and hepatocellular senescence: a causal relationship?Virchows Archiv : an international journal of pathology · 2024Article
- Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH.Biomedicines · 2024Article
- Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver.Annual review of physiology · 2023Review
- Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells.Cellular signalling · 2022Article
- Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration.World journal of gastroenterology · 2020Article
- A case of small hepatocellular carcinoma with malignant ductular reaction.International journal of clinical and experimental pathology · 2020Article
- The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases.Frontiers in medicine · 2020Review
- Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.Hepatology (Baltimore, Md.) · 2019Review
- Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.International journal of molecular sciences · 2018Review
- Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia.Pediatric surgery international · 2017Article
- Can a fibrotic liver afford epithelial-mesenchymal transition?World journal of gastroenterology · 2017Review
- Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- A faithful JAGGED1 haploinsufficiency mouse model of arteriohepatic dysplasia (Alagille syndrome) after all.Hepatology (Baltimore, Md.) · 2016Article
- Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation-like Feature Associated with Bile Duct Adenoma.Journal of pathology and translational medicine · 2015Article
- Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure.Frontiers in physiology · 2015Review
- Characterization of animal models for primary sclerosing cholangitis (PSC).Journal of hepatology · 2014Review
- Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells.Hepatology (Baltimore, Md.) · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
This article discusses on the basis of the ductal plate hypothesis the implication of the concept for several liver abnormalities. The occurrence of ductal plates (DP) during liver growth in childhood would explain the paraportal and parenchymal localizations of von Meyenburg complexes in postnatally developed parts of the liver, and their higher incidence in adulthood versus childhood. It partly clarifies the lack of postnatal intrahepatic bile duct development in Alagille syndrome and the reduced number of portal tracts in this disease. Ductular reactions (DRs) in DP configuration are the predominant type of progenitor cell reaction in fulminant necro-inflammatory liver disease, when lack of sufficient parenchymal regeneration results in liver failure. The concept of dissecting DRs explains the micronodular pattern of advanced biliary and alcoholic cirrhosis. The concept explains the DP patterns of bile ducts in several cases of biliary atresia, with implications for diagnosis and prognosis. The hypothesis also has an impact on concepts about stem/progenitor cells and their niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.