ArticlePsychopharmacology2011
Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differences.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell.Biology of sex differences · 2023Article
- Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement.Biomedicines · 2023Article
- Cocaine reward and reinstatement in adolescent versus adult rodents.Frontiers in behavioral neuroscience · 2023Review
- Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.Journal of the experimental analysis of behavior · 2022Article
- Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior.Drug and alcohol dependence · 2021Article
- AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.Pharmacology, biochemistry, and behavior · 2020Review
- Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.Behavioural brain research · 2020Article
- Extinction to amphetamine-associated context in female rats is dependent upon conditioned orienting.Psychopharmacology · 2019Article
- Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats.Psychopharmacology · 2018Article
- How to study sex differences in addiction using animal models.Addiction biology · 2016Review
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats.Drug and alcohol dependence · 2016Article
- Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine.Pharmacology, biochemistry, and behavior · 2016Article
- Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats.Psychopharmacology · 2016Article
- Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use.Behavioural brain research · 2016Review
- Sex differences in drug addiction and response to exercise intervention: From human to animal studies.Frontiers in neuroendocrinology · 2016Review
- Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats.Behavioural pharmacology · 2015Article
- Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex.Behavioural brain research · 2015Article
- Importance of sex differences in impulse control and addictions.Frontiers in psychiatry · 2015Review
- Eating high fat chow and the behavioral effects of direct-acting and indirect-acting dopamine receptor agonists in female rats.Behavioural pharmacology · 2014Article
- Estrous cycle and sex affect cocaine-induced behavioural changes in CD1 mice.Psychopharmacology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
rationaleResearch suggests that age and sex are vulnerability factors for drug abuse. However, few studies have systematically examined their interaction.
objectiveThe purpose of the present study was to examine male and female, adult and adolescent rats under a procedure that measures responding during periods of signaled availability and nonavailability of iv cocaine and food reinforcers.
methodsAdolescent and adult rats lever pressed for iv infusions of cocaine or food pellets under a procedure with three components of signaled availability of the reinforcer alternating with two components of signaled nonavailability. Adolescent rats were removed and then later retested under the same conditions as adults, and a group of adult rats was also removed and retested after a similar number of days. A subset of rats earning cocaine infusions under the initial test was later retested with food pellets under the same behavioral task to assess the influence of prior cocaine exposure on subsequent responding for a nondrug reinforcer.
resultsAdolescents (vs. adults) made more responses during periods of signaled iv cocaine availability and nonavailabiltiy, and adult females responded more than adult males during these periods. Responding during periods of signaled nonavailability of iv cocaine and food did not differ between the initial and subsequent retest conditions in adult rats. Further, adult males and females exposed to cocaine during adolescence responded more during periods of food availability compared to cocaine-naïve adults.
conclusionThese results indicate that sex and age are vulnerability factors in cocaine abuse, and cocaine exposure during critical developmental stages can have long-lasting effects.
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